Jennifer Marie Webster

US Patent:

20090260092, Oct 15, 2009

Filed:

Jun 18, 2009

Appl. No.:

12/487608

Inventors:

Dietrich A. STEPHAN - San Francisco CA, US
Eric M. Reiman - Scottsdale AZ, US
Jennifer Webster - Phoenix AZ, US
Christopher B. Heward - Mesa AZ, US
Pamela Heward - Mesa AZ, US
Andreas Papassotiropoulos - Zurich, CH

Assignee:

Translational Genomics Research Institute - Phoenix AZ
Kronos Science Laboratory - Phoenix AZ

International Classification:

A01K 67/027
C12Q 1/68
G01N 33/53
C40B 30/04
C07H 21/04

US Classification:

800 3, 435 6, 435 71, 506 9, 536 2431, 800 12

Abstract:

The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.