Jeong J Lee

US Patent:

20090182306, Jul 16, 2009

Filed:

Jan 21, 2009

Appl. No.:

12/357195

Inventors:

Jeong Woo Lee - Atlanta GA, US
Mark R. Prausnitz - Atlanta GA, US

Assignee:

Georgia Tech Research Corporation - Atlanta GA

International Classification:

A61M 5/00
B29C 39/42

US Classification:

604506, 604272, 264101

Abstract:

Microneedle devices and methods of manufacture and use thereof are provided. The devices may be used in controlled delivery of drug across or into a biological barrier, such as skin, or fluid withdrawal from a biological barrier. In one case, the device includes a base substrate which comprises a drug dispersed in a swellable matrix material; and one or more microneedles extending from the base substrate, wherein the one or more microneedles comprise a water-soluble or water-swellable material, wherein the one or more microneedles will dissolve or swell following insertion into the biological barrier, providing a transport pathway for the drug to pass from the base substrate into the biological barrier.

US Patent:

20090318846, Dec 24, 2009

Filed:

May 30, 2008

Appl. No.:

12/130728

Inventors:

Mark R. Prausnitz - Atlanta GA, US
Mark G. Allen - Atlanta GA, US
Jung-Hwan Park - Gyunggi-do, KR
Jeong Woo Lee - Atlanta GA, US
Priya D. Gadiraju - Atlanta GA, US

Assignee:

Georgia Tech Research Corporation - Atlanta GA

International Classification:

A61N 1/30
A61B 18/18

US Classification:

604 20, 606 41

Abstract:

The various embodiments of the present invention relate generally to methods and apparatus for surface ablation. More particularly, various embodiments of the present invention are related to methods and apparatus for ablation of barrier surfaces, such as skin, to increase the permeability of the barrier surface. Embodiments of the present invention comprise rapid thermo-mechanical ablation of the skin by a microfluidic jet generated by an arc discharge to produce micron-scale holes localized to the stratum corneum, which increases skin permeability.