Jerald K Rasmussen

US Patent:

6376619, Apr 23, 2002

Filed:

Apr 7, 1999

Appl. No.:

09/287379

Inventors:

Kurt J. Halverson - Lake Elmo MN
Sanjay L. Patil - Aliso Viejo CA
Jerald K. Rasmussen - Stillwater MN

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

C08F 830

US Classification:

5253303, 5253305, 5253306, 5253337, 525375, 525383, 525384

Abstract:

High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.

US Patent:

6379952, Apr 30, 2002

Filed:

Feb 1, 1999

Appl. No.:

09/240829

Inventors:

Jerald K. Rasmussen - Stillwater MN
Patrick L. Coleman - Minneapolis MN

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

C12N 506

US Classification:

435325, 435180, 435181, 435261, 435372, 435395, 530413, 530815, 530816

Abstract:

Azlactone-functional supports are used to provide cell selection from a mixture such as bone marrow or peripheral blood having a desired target cell population. An azlactone-functional support is derivatized by covalently coupling to the support a biologically active substance that binds the target cells. A mixture containing the target cells is contacted with the derivatized support to bind the target cells to the biologically active substance, and unbound remaining mixture is removed from the support. Bound cells may be eluted from the support to obtain purified target cells. Biologically active substances include antibodies, lectins, proteins, antigens and avidin. The biologically active substance may directly or indirectly bind cells in the mixture. Indirect binding may be through a second, intermediary biologically active substance that is bifunctional. The azlactone-functional support is provided by incorporating an azlactone moiety into a base polymer support that has been selected by prescreening base polymer supports with a cell mixture to identify a base polymer support having minimal nonspecific binding of cells in the mixture.

US Patent:

6548607, Apr 15, 2003

Filed:

Jan 30, 2002

Appl. No.:

10/060798

Inventors:

Kurt J. Halverson - Lake Elmo MN
Sanjay L. Patil - Aliso Viejo CA
Jerald K. Rasmussen - Stillwater MN

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

C08F 830

US Classification:

525375, 428451, 428518, 428513, 5253303, 5253305, 5253306, 5253337, 525383, 525384

Abstract:

High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.

US Patent:

6573338, Jun 3, 2003

Filed:

Jan 30, 2002

Appl. No.:

10/060794

Inventors:

Kurt J. Halverson - Lake Elmo MN
Sanjay L. Patil - Aliso Viejo CA
Jerald K. Rasmussen - Stillwater MN

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

C08F 870

US Classification:

525375, 428451, 428518, 428523, 5253303, 5253305, 5253306, 5253337, 525383, 525384

Abstract:

High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.

US Patent:

6783838, Aug 31, 2004

Filed:

Apr 30, 2001

Appl. No.:

09/845946

Inventors:

Patrick L. Coleman - Minneapolis MN
Kurt J. Halverson - Lake Elmo MN
James I. Hembre - Plymouth MN
Sanjay L. Patil - Minneapolis MN
Anila Prabhu - Woodbury MN
Raj Rajagopal - Woodbury MN
Jerald K. Rasmussen - Stillwater MN
Barbara C. Swenson - North St. Paul MN
Patrick S. Quint - St. Paul MN

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

B23B 500

US Classification:

428152, 428141, 428174, 428334, 428335, 428500, 436 6, 436180, 530810, 530816

Abstract:

A coated laminate having an ionic surface including a shrinkable polymeric film, an ionic coating and, optionally, a hydrogel is disclosed. A method for transferring sample molecules from a matrix to a coated laminate having an ionic surface also is disclosed.

US Patent:

6787635, Sep 7, 2004

Filed:

Apr 5, 2001

Appl. No.:

09/827107

Inventors:

Jerald K. Rasmussen - Stillwater MN
Larry R. Krepski - White Bear Lake MN

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

C07K 104

US Classification:

530334, 522113, 522134, 524 1, 524 17

Abstract:

Functionalized supports and methods for solid phase synthesis. Preferably, the functionalized support is azlactone-functionalized.

US Patent:

6794458, Sep 21, 2004

Filed:

May 18, 2001

Appl. No.:

09/860944

Inventors:

Louis C. Haddad - Mendota Heights MN
James I. Hembre - Plymouth MN
Jerald K. Rasmussen - Stillwater MN
Daniel Sarpong - Maplewood MN

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

C08C 2602

US Classification:

5253267, 5253268, 428361, 428370, 428403, 4284111

Abstract:

Surface coatings including azlactone-functional hydrogels and articles with the coatings disposed thereon are disclosed. Methods of making the coating and controlling the gellation time of the hydrogels are also disclosed.

US Patent:

6841258, Jan 11, 2005

Filed:

Jan 30, 2002

Appl. No.:

10/060799

Inventors:

Kurt J. Halverson - Lake Elmo MN, US
Sanjay L. Patil - Aliso Viejo CA, US
Jerald K. Rasmussen - Stillwater MN, US

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

B32B 1312

US Classification:

428451, 428518, 428523, 5253303, 5253305, 5253306, 5253307, 525375, 525383, 525384

Abstract:

High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.