Jerome S Brody

US Patent:

20070148650, Jun 28, 2007

Filed:

Nov 12, 2004

Appl. No.:

10/579376

Inventors:

Jerome Brody - Newton MA, US
Avrum Spira - Newton MA, US

Assignee:

Trustees of Boston University - Boston MA

International Classification:

C12Q 1/68
C12M 3/00
A61B 17/00

US Classification:

435006000, 435287200, 606190000

Abstract:

The present invention is directed to a scraping instrument for collection of a biological sample, and a non-invasive method for obtaining nucleic acid from buccal mucosa epithelial cells using the scraping instrument. Such nucleic acid can be used for example for gene expression profiling, including to assess lung disease risk associated with airway pollutants.

US Patent:

20090061454, Mar 5, 2009

Filed:

Mar 8, 2007

Appl. No.:

12/282320

Inventors:

Jerome S. Brody - Newton MA, US
Avrum Spira - Newton MA, US
Jeffrey S. Berman - Cambridge MA, US
Anthony W. O'Regan - Galway, IE

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, such as lung cancer.

US Patent:

20090186951, Jul 23, 2009

Filed:

Sep 19, 2008

Appl. No.:

12/234588

Inventors:

Jerome S. Brody - Boston MA, US
Avrum Spira - Newton MA, US
Adam Gustafson - Portland OR, US
Andrea Bild - Salt Lake City UT, US

International Classification:

A61K 31/05
C12Q 1/68
C40B 30/04
C40B 40/08
A61P 35/00

US Classification:

514734, 435 6, 506 9, 506 17

Abstract:

The invention provides the identification of oncogenic pathways activated in cytologically normal airway cells of individuals having or at risk of having lung disease, as well as specific gene expression patterns (biomarkers) associated with pathway activation. These biomarkers and pathways may provide prognostic and/or diagnostic indicators in lung disease, e.g., lung cancer. Additionally, these pathways and biomarkers may provide therapeutic targets for the treatment of lung disease, as well as markers for the assessment of treatment efficacy.

US Patent:

20090311692, Dec 17, 2009

Filed:

Jan 9, 2009

Appl. No.:

12/351484

Inventors:

Jerome S. Brody - Newton MA, US
Avrum Spira - Newton MA, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention is directed to a scraping instrument for collection of a biological sample, and a non-invasive method for obtaining nucleic acid from buccal mucosa epithelial cells using the scraping instrument. Such nucleic acid can be used for example for gene expression profiling, including to assess lung disease risk associated with airway pollutants.

US Patent:

20100035244, Feb 11, 2010

Filed:

Apr 14, 2006

Appl. No.:

11/918588

Inventors:

Jerome S. Brody - Newton MA, US
Avrum Spira - Boston MA, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis with bronchoscopy. The methods of the invention provide far superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, particularly in individuals who are exposed to air pollutants, such as cigarette or cigar smoke, smog, asbestos and the like air contaminants or pollutants.

US Patent:

20110190150, Aug 4, 2011

Filed:

Sep 17, 2010

Appl. No.:

12/884714

Inventors:

JEROME S. BRODY - NEWTON MA, US
AVRUM SPIRA - NEWTON MA, US

International Classification:

C12Q 1/68
C40B 30/04
H01J 49/26

US Classification:

506 9, 435 618, 435 61, 435 617, 435 611, 435 612, 250282

Abstract:

The present invention is directed to a scraping instrument for collection of a biological sample, and a non-invasive method for obtaining nucleic acid from buccal mucosa epithelial cells using the scraping instrument. Such nucleic acid can be used for example for gene expression profiling, including to assess lung disease risk associated with airway pollutants.

US Patent:

20110217717, Sep 8, 2011

Filed:

Nov 5, 2010

Appl. No.:

12/940840

Inventors:

Jerome S. Brody - Newton MA, US
Avrum Spira - Newton MA, US
Jeffrey S. Berman - Cambridge MA, US
Anthony W. O'Regan - Galway, IE

International Classification:

C12Q 1/68

US Classification:

435 614

Abstract:

The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, such as lung cancer.

US Patent:

20120041686, Feb 16, 2012

Filed:

Aug 26, 2010

Appl. No.:

12/869525

Inventors:

JEROME S. BRODY - NEWTON MA, US
AVRUM SPIRA - NEWTON MA, US
JENNIFER E. BEANE - RIO RANCHO NM, US
MARC E. LENBURG - BERKELEY CA, US

International Classification:

G06F 19/20

US Classification:

702 20

Abstract:

The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis with bronchoscopy. The methods of the invention provide far superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, particularly in individuals who are exposed to air pollutants, such as cigarette or cigar smoke, smog, asbestos and the like air contaminants or pollutants.