Emile M. Bellott - Beverly MA, US Dongsheng Bu - Piscataway NJ, US James J. Childs - Bolton MA, US Christopher Lambert - Hudson MA, US Hubert A. Nienaber - Newburyport MA, US Shirley J. Shi - Lexington MA, US Zhaolin Wang - Wellesley MA, US Jerome J. Workman - Madison WI, US Alex R. Zelenchuk - Stoughton MA, US
Assignee:
Masimo Laboratories, Inc. - Irvine CA
International Classification:
A61K 49/00
US Classification:
424 91
Abstract:
Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
Jerome J. Workman - Madison WI, US Stephen R. Lowry - Madison WI, US Nicholas Simon Nunn - Verona WI, US Kathleen J. Schulting - Oregon WI, US
Assignee:
Thermo Electron Scientific Instruments LLC - Madison WI
International Classification:
G06F 7/00 G06F 17/30
US Classification:
707705, 707749, 702 27, 702 28, 702104
Abstract:
A system is provided wherein spectrometer measurements, and/or measurements from other analytical instruments, are transmitted to a processing station which determines the component substances of the sample(s) subjected to the measurements. The names of the component substances are then inserted into database search queries related to matters such as handling precautions, causes/sources of the substances, remedies and neutralizing agents for the substances, regulations related to the substances, etc. The results of the search queries are then provided to the personnel who made the measurements, preferably wirelessly and almost immediately after the measurements were made. The system therefore provides nearly immediate guidance as to what substances are present and how to handle them, which can be useful for inexperienced personnel in hazardous response, contraband detection, industrial process control, and other situations.
Smmr (Small Molecule Metabolite Reporters) For Use As In Vivo Glucose Biosensors
Emile M. Bellott - Beverly MA, US Dongsheng Bu - Piscataway NJ, US James J. Childs - Bolton MA, US Christopher Lambert - Hudson MA, US Hubert A. Nienaber - Newburyport MA, US Shirley J. Shi - Lexington MA, US Zhaolin Wang - Wellesley MA, US Jerome J. Workman - Madison WI, US Alex R. Zelenchuk - Stoughton MA, US
Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatuses, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more biologically active molecules found in skin.
Jerome Workman - Brookline MA, US Christopher Lambert - Hudson MA, US
International Classification:
C12Q001/54
US Classification:
435/014000
Abstract:
This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatus, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more analytes or parameters found in skin.
Smmr (Small Molecule Metabolite Reporters) For Use As In Vivo Glucose Biosensors
Emile Bellott - Beverly MA, US Dongsheng Bu - Piscataway NJ, US James Childs - Bolton MA, US Christopher Lambert - Hudson MA, US Hubert Nienaber - Worcester MA, US Shirley Shi - Lex MA, US Zhaolin Wang - Wellesley MA, US Jerome Workman - Madison WI, US Alex Zelenchuk - Stoughton MA, US
International Classification:
A61K 49/00 C07F 5/02
US Classification:
424009600, 549213000, 546013000
Abstract:
Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
- BROOKFIELD CT, US Jerome J. Workman - DANBURY CT, US
International Classification:
H01J 49/00
US Classification:
702104
Abstract:
Aspects of spectrometer reference calibration are described. In one embodiment, a diagnostic measurement for evaluation of an aspect of calibration in spectroscopy is performed. A result of the diagnostic measurement is analyzed to determine a deviation from an expected result. Based on the analysis, a correction algorithm may be applied to the aspect of calibration, in view of the deviation. In some embodiments, a product model diagnostic measurement is also performed for further evaluation of the aspect of calibration. A result of the product model diagnostic measurement is analyzed to determine a product model deviation from an expected result of the product model diagnostic measurement, and a product model correction algorithm is applied, if necessary. According to aspects of the embodiments described herein, using reference standards permits reconstruction of calibration parameters without any need for a master instrument or other forms of calibrated reference instrumentation.
Smmr (Small Molecule Metabolite Reporters) For Use As In Vivo Glucose Biosensors
- Irvine CA, US Dongsheng Bu - Piscataway NJ, US James J. Childs - Bolton MA, US Christopher Lambert - Hudson MA, US Hubert A. Nienaber - Newburyport MA, US Shirley J. Shi - Lexington MA, US Zhaolin Wang - Wellesley MA, US Jerome J. Workman - Madison WI, US Alex R. Zelenchuk - Stoughton MA, US
Assignee:
Cercacor Laboratories, Inc - Irvine CA
International Classification:
A61K 49/00 C07F 5/02
US Classification:
424 96, 549213, 546 13, 562 7
Abstract:
Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
Isbn (Books And Publications)
The Handbook of Organic Compounds: Nir, Ir, Raman, and Uv-Vis Spectra Featuring Polymers and Surfactans
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