Ji I Li

US Patent:

7709611, May 4, 2010

Filed:

Aug 4, 2005

Appl. No.:

11/197665

Inventors:

Ji Li - Thousand Oaks CA, US
Wenyan Shen - Thousand Oaks CA, US
Hsieng Sen Lu - Westlake Village CA, US
William Gleason Richards - Thousand Oaks CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07K 16/00
C07K 16/32
A61K 39/00
A61K 39/395

US Classification:

53038824, 5303871, 5303873, 5303879, 5303881, 4241301, 4241331, 4241411, 4241521, 4241581

Abstract:

The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

US Patent:

8101184, Jan 24, 2012

Filed:

Oct 21, 2009

Appl. No.:

12/603303

Inventors:

Ji Li - Thousand Oaks CA, US
Wenyan Shen - Wayne PA, US
Hsieng Sen Lu - Westlake Village CA, US
William Gleason Richards - Thousand Oaks CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 39/00
A61K 39/395

US Classification:

4241581, 4241301, 4241331, 4241411, 4241521

Abstract:

The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

US Patent:

20120087912, Apr 12, 2012

Filed:

Dec 12, 2011

Appl. No.:

13/323566

Inventors:

Ji Li - Thousand Oaks CA, US
Wenyan Shen - Wayne PA, US
Hsieng Sen Lu - Westlake Village CA, US
William Gleason Richards - Thousand Oaks CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

A61K 39/395
C12N 5/10
C12N 15/63
C07K 16/18
A61P 1/00
A61P 21/00
A61P 3/10
C07H 21/04
A61P 19/02
A61P 29/00
A61P 25/00
A61P 27/02
A61P 13/12
A61P 11/00
A61P 17/00
A61P 25/28
A61P 25/16
C12P 21/06

US Classification:

4241301, 435 696, 435354, 4353201, 5303871, 5303873, 5303879, 5303881, 536 2353

Abstract:

The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

US Patent:

20220231526, Jul 21, 2022

Filed:

Jan 21, 2022

Appl. No.:

17/581839

Inventors:

- Basel, CH
Igor Y. Gofman - Croton-on-Hudson NY, US
Cameron M. Young - Tarrytown NY, US
Ji Li - Wayne NJ, US

International Classification:

H02J 7/00
A61B 5/00
A61B 5/145

Abstract:

A base unit of a wearable device for continuous analyte monitoring includes a cup configured to receive a power source. A first power source contact is at least partially located in the cup and configured to electrically contact a first terminal of the power source in response to the power source being received in the cup. At least one base contact is electrically coupled to the first power source contact, the at least one base contact configured to electrically contact at least one transmitter contact of a transmitter unit in response to the transmitter unit and the base unit being coupled together. Numerous other embodiments are provided.

US Patent:

20210369152, Dec 2, 2021

Filed:

May 28, 2021

Appl. No.:

17/334103

Inventors:

- Basel, CH
Igor Y. Gofman - Croton-on-Hudson NY, US
Wei Dale Zhang - Dayton NJ, US
Ji Li - Wayne NJ, US
Christopher A. Dionisio - Butler NJ, US

International Classification:

A61B 5/145
A61B 5/00

Abstract:

In one or more embodiments, a base unit of a wearable device for continuous analyte monitoring may include sensor memory circuitry and a sensor assembly. The sensor memory circuitry stores information (data) of at least one parameter of at least one component of the base unit, such as, e.g., the sensor assembly. The base unit is configured to couple to a transmitter unit of the wearable device and to transfer the information to the transmitter unit. Analyte determinations are made based at least in part on the information. Numerous other embodiments are provided.