Jian T Cao

US Patent:

6770446, Aug 3, 2004

Filed:

Apr 24, 2000

Appl. No.:

09/556390

Inventors:

Kathleen H. Young - Newtown PA
Jian Cao - Monmouth Junction NJ

Assignee:

Wyeth - Madison NJ

International Classification:

G01N 3353

US Classification:

435 71, 82542, 825421

Abstract:

This invention relates to novel modified host cells which express heterologous fused proteins and methods of screening for test samples having peptide-binding activity; wherein the modified host cell comprises: (a) a gene sequence encoding a heterologous fusion protein; said fusion protein comprising a first peptide of a peptide binding pair, or segment of said first peptide, which is joined to either a DNA binding domain or its corresponding transcriptional activation domain of a transcriptional activation protein; (b) a gene sequence encoding a heterologous fusion protein, said fusion protein comprising a second peptide of the peptide binding pair in (a), or a segment thereof, fused to either a DNA binding domain or its corresponding transcriptional activation domain, whichever one is not employed in (a); (c) a luciferase gene operatively associated with the transcriptional activation protein, or a portion thereof; (d) optionally, a deletion or mutation in the chromosomal DNA of the host cell for the transcriptional activation protein if present in the selected host cell.

US Patent:

20070077934, Apr 5, 2007

Filed:

Sep 28, 2006

Appl. No.:

11/541284

Inventors:

Aik Chindapol - Princeton NJ, US
Jian Cao - New Haven CT, US

International Classification:

H04Q 7/20

US Classification:

455447000

Abstract:

The reuse partitioning problem for a cellular orthogonal frequency division multiple access (OFDMA) system with dynamic subcarrier allocation is considered. One objective is to allocate the network resources in an efficient way in order to maximize the system's total throughput under individual user's quality-of-service (QoS) constraint. A suboptimal two-step approach is used where the radio network controller (RNC) solves the network planning problem and each base station (BS) solves the cell throughput maximization problem. Compared with the optimal resource allocation scheme, the approach described herein has much lower computational complexity in the RNC. Moreover, the communication overhead between each BS and the RNC is reduced substantially which renders our approach more practical for delay sensitive applications. Throughput increase is demonstrated