Devices, systems, kits, and methods for detecting and/or identifying a plurality of spectrally labeled bodies well-suited for performing multiplexed assays. By spectrally labeling the beads with materials which generate identifiable spectra, a plurality of beads may be identified within the fluid. Reading of the beads is facilitated by restraining the beads in arrays, and/or using a focused laser.
Jian Jin - Berkeley CA, US Robert M. Glaeser - Berkeley CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
G21K 5/04 H01J 37/24
US Classification:
250396R, 250309, 250311
Abstract:
A microfabricated electron phase shift element is used for modifying the phase characteristics of an electron beam passing though its center aperture, while not affecting the more divergent portion of an incident beam to selectively provide a ninety-degree phase shift to the unscattered beam in the back focal plan of the objective lens, in order to realize Zernike-type, in-focus phase contrast in an electron microscope. One application of the element is to increase the contrast of an electron microscope for viewing weakly scattering samples while in focus. Typical weakly scattering samples include biological samples such as macromolecules, or perhaps cells. Preliminary experimental images demonstrate that these devices do apply a ninety degree phase shift as expected. Electrostatic calculations have been used to determine that fringing fields in the region of the scattered electron beams will cause a negligible phase shift as long as the ratio of electrode length to the transverse feature-size aperture is about 5:1. Calculations are underway to determine the feasibility of aspect smaller aspect ratios of about 3:1 and about 2:1.
Performing An In-Service Software Reload On A Network Device
Prabhakara R. Yellai - San Jose CA, US Rengabashyam Srinivas - Fremont CA, US Jan Medved - Pleasanton CA, US Jian Jin - San Jose CA, US
Assignee:
Cisco Technology, Inc. - San Jose CA
International Classification:
G06F 9/00 G06F 15/16
US Classification:
709221, 709227, 709242, 713 2
Abstract:
A software reload is executed. The hardware associated with the network device continues to forward network traffic during the software reload. Also, a kernel of the network device operates unaffected in a protected address space throughout the software reload. Further, the kernel preserves local checkpointed and shared memory data. Application processes running on the network node are shut down gracefully. The reloaded software is brought up and the network device is resynchronized.
Devices, systems, kits, and methods for detecting and/or identifying a plurality of spectrally labeled bodies well-suited for performing multiplexed assays. By spectrally labeling the beads with materials which generate identifiable spectra, a plurality of beads may be identified within the fluid. Reading of the beads is facilitated by restraining the beads in arrays, and/or using a focused laser.
Performing An In-Service Software Reload On A Network Device
Prabhakara R. Yellai - San Jose CA, US Rengabashyam Srinivas - Fremont CA, US Jan Medved - Pleasanton CA, US Jian Jin - San Jose CA, US
Assignee:
Cisco Technology, Inc. - San Jose CA
International Classification:
G06F 9/00
US Classification:
709221, 709228, 709242
Abstract:
A software reload is executed. The hardware associated with the network device continues to forward network traffic during the software reload. Also, a kernel of the network device operates unaffected in a protected address space throughout the software reload. Further, the kernel preserves local checkpointed and shared memory data. Application processes running on the network node are shut down gracefully. The reloaded software is brought up and the network device is resynchronized.
Stephen Empedocles - Mountain View CA, US Andrew Watson - Belmont CA, US Jian Jin - Berkeley CA, US
Assignee:
Quantum Dot Corporation - Hayward CA
International Classification:
G01N033/53 G06F019/00 G01N033/48 G01N033/50
US Classification:
435/007100, 702/019000
Abstract:
Improved devices, systems, and methods for sensing and/or identifying signals from within a signal detection region are well-suited for identification of spectral codes. Large numbers of independently identifiable spectral codes can be generated by quite small bodies, and a plurality of such bodies or probes may be present within a detection region. Simultaneously imaging of identifiable spectra from throughout the detection region allows the probes to be identified. As the identifiable spectra can be treated as being generated from a point source within a much larger detection field, a prism, diffractive grading, holographic transmissive grading, or the like can spectrally disperse the images of the labels across a sensor surface. A CCD can identify the relative wavelengths of signals making up the spectra. Absolute signal wavelengths may be identified by determining positions of the labels, by an internal wavelength reference within the spectra, or the like.
Network System-Wide Error Handling Utilizing Control Bit Modification
Shaofeng Wu - Sunnyvale CA, US Jerry Kuo - San Jose CA, US Po-Shen Lai - San Jose CA, US Jian Jin - San Jose CA, US Autumn Niu - San Jose CA, US
Assignee:
Zarlink Semiconductor V.N. Inc. - Irvine CA
International Classification:
H04L012/28
US Classification:
370/389000
Abstract:
A communication interface for processing errors between network devices. The communication interface includes an output interface of a first network device for generating output control information and parity information of output information transmitted therefrom, and an error-handling interface of a second network device, which error-handling interface is in operative communication with the output interface to process the output control information and the parity information of the output information by, checking parity of the parity information of the output information received from the first network device, terminating the output information when an error in the parity is detected, and recovering a boundary of the output information when an error in the output control information is detected.
Stephen Empedocles - Mountain View CA, US Andrew Watson - Belont CA, US Jian Jin - Berkeley CA, US
International Classification:
G01J 3/28 G01J 3/00
US Classification:
356326000, 356300000
Abstract:
Devices, systems, kits, and methods for detecting and/or identifying a plurality of spectrally labeled bodies well-suited for performing multiplexed assays. By spectrally labeling the beads with materials which generate identifiable spectra, a plurality of beads may be identified within the fluid. Reading of the beads is facilitated by restraining the beads in arrays, and/or using a focused laser.
Roche - Nutley, NJ 07110 since Sep 2011
Principle Associate
Roche - Nutley, NJ 07110 Jun 2010 - Oct 2011
Associate Principle Scientist
Pfizer 2003 - Jan 2011
Senior Associate Scientist
Pfizer 1999 - 2003
Assistant Scientist II
Education:
Villanova University 1997 - 1999
MS, Organic Chemistry
Lanzhou University 1986 - 1990
BS, Analytical Chemistry
Skills:
Organic Synthesis Medicinal Chemistry Drug Discovery Synthetic Organic Chemistry HPLC LC-MS NMR Organic Chemistry Pharmaceutical Industry Drug Design Chemistry Chromatography Mass Spectrometry NMR spectroscopy Crystallization GMP Drug Development Analytical Chemistry GLP Process Chemistry
Languages:
English Chinese
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