Jian Sen Li

US Patent:

6576437, Jun 10, 2003

Filed:

Apr 27, 2001

Appl. No.:

09/844908

Inventors:

Frank Mercurio - San Diego CA
Hengyi Zhu - San Diego CA
Miguel Barbosa - San Diego CA
Jian Wu Li - San Diego CA
Brion W. Murray - San Diego CA

Assignee:

Signal Pharmaceuticals, Inc. - San Diego CA

International Classification:

C12Q 148

US Classification:

435 15, 435 681, 435194

Abstract:

Compositions and methods are provided for treating NF- B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF- B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF- B activation.

US Patent:

6744948, Jun 1, 2004

Filed:

Jun 20, 2002

Appl. No.:

10/064201

Inventors:

Bo Pi - Carlsbad CA
Shulai Zhao - Encinitas CA
Zheng Chen - Carlsbad CA
Robert Morse - Carlsbad CA
Jian Li - Carlsbad CA

Assignee:

Oluma, Inc. - Carlsbad CA

International Classification:

G02B 626

US Classification:

385 30, 385 28, 385 48

Abstract:

Fiber tap monitors formed on side-polished fiber coupling ports based on evanescent coupling.

US Patent:

7285654, Oct 23, 2007

Filed:

Jan 8, 2003

Appl. No.:

10/338462

Inventors:

Frank Mercurio - San Diego CA, US
Hengyi Zhu - San Diego CA, US
Miguel Barbosa - San Diego CA, US
Jian Wu Li - San Diego CA, US
Brion W. Murray - San Diego CA, US

Assignee:

Signal Pharmaceuticals - San Diego CA

International Classification:

C02H 21/04
C12N 9/12
C12N 15/63
C12N 1/20
C12N 15/00

US Classification:

536 232, 435194, 4353201, 4352523, 43525233, 435325

Abstract:

Compositions and methods are provided for treating NF-κB-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-κB cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-κB activation.

US Patent:

7346240, Mar 18, 2008

Filed:

Dec 1, 2003

Appl. No.:

10/726026

Inventors:

Yi He - Carlsbad CA, US
Jian Li - Carlsbad CA, US

Assignee:

Intelligent Fiber Optic Systems, Inc. - Santa Clara CA

International Classification:

G02B 6/26
G02B 6/42

US Classification:

385 48

Abstract:

Integrated fiber tap monitors with variable optical attenuators where light from an input fiber is reflected to the output fiber and a tap is generated from measuring transmission at the reflection.

US Patent:

7492994, Feb 17, 2009

Filed:

Jan 7, 2008

Appl. No.:

11/970303

Inventors:

Yi He - Carlsbad CA, US
Jian Li - Carlsbad CA, US

Assignee:

Intelligent Fiber Optic Systems, Inc. - Santa Clara CA

International Classification:

G02B 6/26
G02B 6/42

US Classification:

385 48

Abstract:

Integrated fiber tap monitors with variable optical attenuators where light from an input fiber is reflected to the output fiber and a tap is generated from measuring transmission at the reflection.

US Patent:

7711066, May 4, 2010

Filed:

Nov 4, 2005

Appl. No.:

11/718506

Inventors:

Yi Jiang - San Diego CA, US
Jian Li - Gainesville FL, US

Assignee:

University of Florida Research Foundation, Inc. - Gainesville FL

International Classification:

H04L 25/49

US Classification:

375296, 375285

Abstract:

A multi-input-multi-output (MIMO) communications system is provided for conveying signals over a MIMO channel. The system includes a precoder for precoding a signal based upon a uniform channel decomposition scheme. The system further comprises a transmitter in communication with the precoder for conveying the precoded signal over a subchannel of the MIMO channel.

US Patent:

7759476, Jul 20, 2010

Filed:

Oct 22, 2007

Appl. No.:

11/876570

Inventors:

Frank Mercurio - San Diego CA, US
Hengyi Zhu - San Diego CA, US
Miguel Barbosa - San Diego CA, US
Jian Wu Li - San Diego CA, US
Brion W. Murray - San Diego CA, US

Assignee:

Signal Pharmaceuticals - San Diego CA

International Classification:

C07H 21/04

US Classification:

536 232

Abstract:

Compositions and methods are provided for treating NF-κB-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-κB cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-κB activation.

US Patent:

62585797, Jul 10, 2001

Filed:

Aug 13, 1997

Appl. No.:

8/910820

Inventors:

Frank Mercurio - San Diego CA
Hengyi Zhu - San Diego CA
Miguel Barbosa - San Diego CA
Jian Wu Li - San Diego CA
Brion W. Murray - San Diego CA

Assignee:

Signal Pharmaceuticals, Inc. - San Diego CA

International Classification:

C12N 912

US Classification:

435194

Abstract:

Compositions and methods are provided for treating NF-. kappa. B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-. kappa. B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-. kappa. B activation.