Jian Wei Li

US Patent:

6723761, Apr 20, 2004

Filed:

Feb 15, 1996

Appl. No.:

08/601785

Inventors:

David E. Thomas - Northbridge MA
Jian Xing Li - Westborough MA

Assignee:

Bose Corporation - Framingham MA

International Classification:

C08J 900

US Classification:

521 82, 521 78, 521 92, 521182, 521155

Abstract:

A method for forming microcellular foams that causes the material to expand uniaxially during the foaming process, and a method for forming objects from the foam. Liquid crystal polymers or polymers having a planar crystalline structure are saturated with a fluid, normally a gas such as carbon dioxide. The ambient conditions are changed such that the fluid is in a supersaturated state, and the material is brought to near its glass transition temperature to induce the formation of nonspherical elongated gas-filled cells. A process for making objects, such as transducer diaphragms, from microcellular foams includes the step of forming the objects prior to the foaming process.

US Patent:

6911891, Jun 28, 2005

Filed:

Jan 18, 2002

Appl. No.:

10/052667

Inventors:

Jin Qiu - Cambridge MA, US
Alexander H. Slocum - One Merrill Crossing Bow NH, US
Jeffrey H. Lang - Sudbury MA, US
Ralf Struempler - Gebenstorf, CH
Michael P. Brenner - Needham MA, US
Jian Li - Cambridge MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

H01H037/52
H01H037/54

US Classification:

337 53, 337 36, 337 16, 337365, 60529

Abstract:

A bistable structure provided by the invention is characterized as including a deflection element that has mechanically constrained end points and a compliant span between the end points that is substantially free to deflect between two stable positions when a force is applied at a point along the span. The deflection element span is provided, as-fabricated, curved in one of the two stable positions and in a mechanically unstressed condition along the length of the span. The as-fabricated curve of the deflection element span includes a curve maxima at a point along the span length that is at least about of the span length from the end points of the span. The deflection element span is constrained to substantially prohibit development of a second bending mode that is characteristic for the span as the element deflects between the two stable positions.

US Patent:

7850959, Dec 14, 2010

Filed:

Oct 12, 2004

Appl. No.:

10/575127

Inventors:

Jian Li - West Roxbury MA, US
Jue-Lon Shie - Acton MA, US
Roger J. Laham - Brookline MA, US

Assignee:

Beth Israel Deaconess Medical Center - Boston MA

International Classification:

A61K 38/00
A61K 48/00
C12N 15/00
C12N 15/06
C12N 15/07

US Classification:

424 9321, 514 2, 514 21, 514 44 R, 435455

Abstract:

The present invention features methods and compositions for preventing, reducing, or treating hypoxia and pathological disorders involving abnormal angiogenesis (e. g. , conditions involving decreases or increases in blood flow, respectively). Where an increase in angiogenesis is desired, the mammal being treated for an ischemic condition is provided with Related Transcriptional Enhancer Factor-1 (RTEF-1; as a recombinant polypeptide or as an expression vector) sufficient to increase expression of VEGF, FGFR, or COX-2. This results in a concomitant increase in angiogenesis. Conversely, a mammal being treated for a hypervascular condition is administered a composition that reduces the levels of RTEF-1, thereby reducing the expression of VEGF, FGFR, or COX-2, which results in a decrease in angiogenesis. Also disclosed are screening methods that make use of RTEF-1 for the identification of novel therapeutics for the treatment, prevention, or reduction of pathological disorders involving hypoxia or abnormal angiogenesis, namely, ischemic or hypervascular conditions.

US Patent:

20030009898, Jan 16, 2003

Filed:

Jan 18, 2002

Appl. No.:

10/052726

Inventors:

Alexander Slocum - Bow NH, US
Jin Qiu - Cambridge MA, US
Joachim Sihler - Somerville MA, US
Roger Cortesi - Washington DC, US
Micah Smith - Rawlings MD, US
Jian Li - Cambridge MA, US
Eun Suh - Cambridge MA, US
Shorya Awtar - Brighton MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

G01D021/00

US Classification:

033/706000

Abstract:

An instrument for enabling a precise determination of the force-displacement characteristics of a compliant structure, including both in-plane and out-of-plane structure deflection, is provided by the invention. The instrument includes a fixture that is oriented for constraining an end of the compliant structure with respect to mechanical ground as the force-displacement characteristic is determined. A mechanical probe of the instrument is disposed relative to the fixture to enable pushing of the probe against a free end of the compliant structure. A mechanical stage is provided, including a support for the probe, and being free with respect to mechanical ground to advance the probe relative to the fixture. This enables pushing of the probe against the free end of the compliant structure. A reference element is connected to the stage, and a displacement transmission element is disposed relative to the mechanical probe and the compliant reference element to transmit deflection of the compliant structure, produced by pushing of the probe, to the compliant reference element. A displacement sensor is disposed relative to the displacement transmission element to measure displacement of the transmission element, and a displacement sensor is disposed relative to the mechanical stage to measure displacement of the mechanical stage. The compliant reference element and the displacement transmission element can be configured with respect to the constraining fixture to accommodate deflection of the compliant structure along more than one axis, e.g., along either of two deflection axes.

US Patent:

20090014296, Jan 15, 2009

Filed:

May 28, 2008

Appl. No.:

12/153979

Inventors:

Alexis Christian Weber - Cambridge MA, US
Alexander H. Slocum - Bow NH, US
Jeffrey Lang - Sudbury MA, US
Sami Kotilainen - Niederrohrdorf, CH
Jian Li - Fremont CA, US

Assignee:

ABB Research Ltd. - Zurich

International Classification:

H01H 57/00
H01H 1/06
H01H 11/04

US Classification:

200181, 200502, 29622

Abstract:

Micro-electromechanical (MEMS) contact configuration is disclosed, comprising a static contact with at least one contact surface and a movable contact with at least one corresponding contact surface. Particularly flat contact surfaces and correspondingly low contact resistance can be achieved, if at least one contact surface plane is formed by a crystal plane of the wafer. Furthermore a method for manufacturing such a contact configuration is proposed, wherein the contact surfaces are obtained by wet anisotropic etching of a silicon wafer, if need be preceded by appropriate masking to expose the to be edged regions only, if need be followed by coating with an electrically conductive layer, e.g., a metal layer.

US Patent:

20230052903, Feb 16, 2023

Filed:

Sep 19, 2022

Appl. No.:

17/947937

Inventors:

- Shenzhen, CN
Lifeng Liu - Sudbury MA, US
Jian Li - Waltham MA, US

Assignee:

HUAWEI TECHNOLOGIES CO., LTD. - Shenzhen

International Classification:

G06N 20/20
G06K 9/62
G06N 5/02
G06F 11/34

Abstract:

This disclosure relates to recommendations made to users based on learned behavior patterns. User behavior data is collected and grouped according labels. The grouped user behavior data is labeled and used to train a machine learning model based on features and tasks associated with the classification. User behavior is then predicted by applying the trained machine learning model to the collected user behavior data, and a task is recommended to the user.

US Patent:

20200291445, Sep 17, 2020

Filed:

Mar 2, 2020

Appl. No.:

16/807147

Inventors:

- Evanston IL, US
Ashty Stephen Karim - Chicago IL, US
Jian Li - Evanston IL, US
Quentin Dudley - Evanston IL, US

International Classification:

C12P 21/02
C12N 15/67

Abstract:

Disclosed are cell-free systems for metabolic engineering, methods for cell-free metabolic engineering, kits for preparing the disclosed systems, and kits for performing the disclosed methods. The disclosed systems, methods, and kits may be utilized to prepare a chemical product or natural product and to optimize conditions for preparing a chemical product or natural product. The disclosed systems, methods, and kits also may be utilized for combinatorial cell-free metabolism engineering.

US Patent:

20200157212, May 21, 2020

Filed:

Jun 8, 2018

Appl. No.:

16/614701

Inventors:

- New York NY, US
- Boston MA, US
Eric M. Bennett - Arlington MA, US
Huilan Gao - West Roxbury MA, US
Zong Sean Juo - Cambridge MA, US
Stefano V. Gulla - Boston MA, US
Christine Huard - Somerville MA, US
Sreekumar R. Kodangattil - Lexington MA, US
Jian Li - Chestnut Hill MA, US
Weining Lu - Boston MA, US
Xueping Fan - Boston MA, US
David J. Salant - Boston MA, US

International Classification:

C07K 16/28
A61P 13/12
C12N 15/85

Abstract:

The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.