Jian Luo Ping Lu

US Patent:

8514268, Aug 20, 2013

Filed:

May 21, 2009

Appl. No.:

12/454707

Inventors:

Morteza Gharib - San Marino CA, US
Jian Lu - Laguna Hills CA, US
Scott Hsieh - Anaheim CA, US
Francisco Pereira - Rome, IT
Alexei Harvard - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

H04N 13/02
A61B 1/04
H04N 7/00
H04N 7/18

US Classification:

348 46, 348 38, 348 45, 348 50, 348 66, 348 94

Abstract:

A method and device for high-resolution three-dimensional (3-D) imaging which obtains camera pose using defocusing is disclosed. The device comprises a lens obstructed by a mask having two sets of apertures. The first set of apertures produces a plurality of defocused images of the object, which are used to obtain camera pose. The second set of optical filters produces a plurality of defocused images of a projected pattern of markers on the object. The images produced by the second set of apertures are differentiable from the images used to determine pose, and are used to construct a detailed 3-D image of the object. Using the known change in camera pose between captured images, the 3-D images produced can be overlaid to produce a high-resolution 3-D image of the object.

US Patent:

8619126, Dec 31, 2013

Filed:

Apr 23, 2008

Appl. No.:

12/150236

Inventors:

Morteza Gharib - San Marino CA, US
Jian Lu - San Gabriel CA, US
Emilio Graff - Pasadena CA, US
Francisco Pereira - Rome, IT

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

H04N 13/02

US Classification:

348 46, 348349, 348E13074, 348E13015, 348E13005, 382154, 345419, 356602

Abstract:

A device and method for three-dimensional (3-D) imaging using a defocusing technique is disclosed. The device comprises a lens, a central aperture located along an optical axis for projecting an entire image of a target object, at least one defocusing aperture located off of the optical axis, a sensor operable for capturing electromagnetic radiation transmitted from an object through the lens and the central aperture and the at least one defocusing aperture, and a processor communicatively connected with the sensor for processing the sensor information and producing a 3-D image of the object. Different optical filters can be used for the central aperture and the defocusing apertures respectively, whereby a background image produced by the central aperture can be easily distinguished from defocused images produced by the defocusing apertures.

US Patent:

20040147447, Jul 29, 2004

Filed:

Mar 1, 2004

Appl. No.:

10/791513

Inventors:

Jian Lu - Green Brook NJ, US
Bruce Gomes - Wilmington DE, US
William Fieles - Wilmington DE, US

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

A61K038/17
C07H021/04
C07K014/715
C07K016/30

US Classification:

514/012000, 530/350000, 530/388220, 536/023500

Abstract:

The present invention provides methods and compositions based on the identification of a Death Domain Expressing Tumor Necrosis Factor Receptor Family Homologue (DETH). The present invention further provides methods and compositions for modulating apoptosis.

US Patent:

20100094138, Apr 15, 2010

Filed:

Jul 27, 2009

Appl. No.:

12/460988

Inventors:

Morteza Gharib - San Marino CA, US
Jian Lu - Laguna Hills CA, US
David Jeon - Pasadena CA, US

International Classification:

A61B 6/00

US Classification:

600478

Abstract:

A device, system, and method for measuring the depth of a material layer such as a blood vessel plaque layer is disclosed. A fiber optic bundle housed in a balloon catheter projects a laser dot toward a conical mirror, which reflects the dot perpendicularly onto the surface of the plaque. The laser dot is reflected back from the plaque layer with a substantially Gaussian intensity profile. The conical mirror directs the reflected image back to the fiber optic bundle, which delivers the image to a sensor. The depth of the plaque layer can be determined by comparing the diameter of the image intensity profile to a pre-obtained normalized data set.

US Patent:

20110037832, Feb 17, 2011

Filed:

Aug 9, 2010

Appl. No.:

12/853181

Inventors:

Morteza Gharib - Altadena CA, US
Jian Lu - Monrovia CA, US
Scott Hsieh - Aroheim CA, US
Francisco Pereira - Rome, IT
Alexei Harvard - Pasadena CA, US
David Jeon - Pasadena CA, US

Assignee:

CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasadena CA

International Classification:

H04N 15/00
G02B 13/16

US Classification:

348 46, 348335, 348E15001

Abstract:

A lens and aperture device for determining 3D information. An SLR camera has a lens and aperture that allows the SLR camera to determine defocused information.

US Patent:

20110074932, Mar 31, 2011

Filed:

Aug 27, 2010

Appl. No.:

12/869919

Inventors:

Morteza Gharib - Altadena CA, US
Jian Lu - Pasadena CA, US
Alexei Harvard - Pasadena CA, US
Scott Hsieh - Anaheim CA, US

Assignee:

CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasadena CA

International Classification:

H04N 13/02

US Classification:

348 50, 348E13074

Abstract:

A lens and aperture device for determining 3D information. A projector projects an optical pattern toward a surface. The camera has at least two off-axis apertures thereon, arranged to obtain an image of the projected pattern including defocused information. The camera is movable between different positions to image the surface from said different positions, and the projector is at a specified angle of at least 5 relative to said camera. A processor carries out a first operation using information received through the apertures to determine a pose of said camera, and to determine three dimensional information about the object based on a degree of deformation of said optical pattern on said surface indicative of a three dimensional surface. An embodiment projects a grid of laser dots and uses laser-dot defocusing for approximate Z and thus grid correspondence, which can greatly increase the working depth of the system.

US Patent:

20110301418, Dec 8, 2011

Filed:

Apr 14, 2011

Appl. No.:

13/087202

Inventors:

Mortez Gharib - Altadena CA, US
Jian Lu - San Gabriel CA, US
David Jeon - Pasadena CA, US

International Classification:

A61B 1/07

US Classification:

600181

Abstract:

A catheter based defocusing imaging system for 3-D tomography reconstruction of endovascular features of interest is disclosed. Without limitation, target sites for imaging include heart valves, calcified heart valves, calcium plastered valve on the heart valve or plaque on the inner wall of the blood vessel of a patient.

US Patent:

20130235165, Sep 12, 2013

Filed:

Nov 19, 2010

Appl. No.:

13/820116

Inventors:

Morteza Gharib - Pasadena CA, US
Alexei Harvard - Pasadena CA, US
Scott Hsieh - Monrovia CA, US
Jian Lu - Monrovia CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

H04N 13/02

US Classification:

348 50

Abstract:

Hardware and software configurations, optionally, for performing profilometry of an object are disclosed. An advantageous imaging device is described. An advantageous approach to determining imager position is also described. Each aspect described may be used independently of the other. Moreover, the teaching may find use in other fields including velocimetry, etc.