Jian Ling Yan

US Patent:

8168769, May 1, 2012

Filed:

Jul 30, 2007

Appl. No.:

12/375518

Inventors:

David B Weiner - Merion PA, US
Jian Yan - Havertown PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C12N 15/11
C12N 15/63

US Classification:

536 231, 4353201

Abstract:

Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed, Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.

US Patent:

8298820, Oct 30, 2012

Filed:

Jan 26, 2010

Appl. No.:

12/694238

Inventors:

David B Weiner - Merion PA, US
Jian Yan - Havertown PA, US
Matthew P Morrow - Philadelphia PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C12N 15/00
A61K 39/145
C12P 21/06
C07H 21/02

US Classification:

4353201, 4242061, 435 691, 435 71, 536 231

Abstract:

Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more Influenza A serotypes using the vaccines that are provided.

US Patent:

8389706, Mar 5, 2013

Filed:

Jan 21, 2010

Appl. No.:

12/691588

Inventors:

David B Weiner - Merion PA, US
Jian Yan - Havertown PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C07H 21/04
C12Q 1/00
C12Q 1/70
C12Q 1/68
C12P 19/34
C12N 7/00
C12N 7/01

US Classification:

536 2372, 536 231, 536 234, 536 237, 435 4, 435 5, 435 61, 435 9132, 435 9133, 4352351

Abstract:

Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV 18 E6 and E7. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HPV are disclosed.

US Patent:

20110184160, Jul 28, 2011

Filed:

Jan 26, 2010

Appl. No.:

12/694216

Inventors:

David B. Weiner - Merion PA, US
Jian Yan - Havertown PA, US
Matthew P. Morrow - Philadelphia PA, US

International Classification:

C07H 21/04

US Classification:

536 231

Abstract:

Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more Influenza A serotpyes using the vaccines that are provided.

US Patent:

20110305664, Dec 15, 2011

Filed:

Jun 10, 2011

Appl. No.:

13/158150

Inventors:

Ruxandra Draghia-Akli - Brussels, BE
David B. Weiner - Merion PA, US
Jian Yan - Havertown PA, US
Dominick Laddy - Germantown MD, US

International Classification:

A61K 39/145
A61K 38/20
A61P 31/16
A61P 37/04
A61P 31/12
A61K 39/395
C12N 15/63

US Classification:

424 852, 4241991, 4241781, 4353201

Abstract:

An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient. The DNA plasmid is capable of expressing a consensus influenza antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal, wherein the consensus influenza antigen comprises consensus hemagglutinin (HA), neuraminidase (NA), matrix protein, nucleoprotein, M2 ectodomain-nucleo-protein (M2e-NP), or a combination thereof. Preferably the consensus influenza antigen comprises HA, NA, M2e-NP, or a combination thereof. The DNA plasmid comprises a promoter operably linked to a coding sequence that encodes the consensus influenza antigen. Additionally, an aspect of the present invention includes methods of eliciting an immune response against a plurality of influenza virus subtypes in a mammal using the DNA plasmid vaccines provided.

US Patent:

20120034256, Feb 9, 2012

Filed:

Oct 29, 2008

Appl. No.:

13/127008

Inventors:

David B. Weiner - Merion PA, US
Krystle A. Lang - Baltimore MD, US
Jian Yan - Havertown PA, US
Ruxandra Draghia-Akli - Brussels, BE
Amir Khan - Narberth PA, US

International Classification:

A61K 39/29
A61P 37/04
C07K 14/08
A61P 31/14
C07H 21/04
C12N 15/63

US Classification:

4241891, 536 2372, 4353201, 4242281, 4241991, 530350

Abstract:

Improved anti-HCV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HCV genotype 1 a/1 b NS3 and NS4A. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HCV are disclosed.

US Patent:

20120053509, Mar 1, 2012

Filed:

Oct 12, 2011

Appl. No.:

13/271576

Inventors:

David B. WEINER - Merion PA, US
Jian YAN - Haverford PA, US

International Classification:

A61M 37/00
A61K 31/7105
A61P 31/14
A61K 39/295
C07K 14/08
A61P 37/04
C07H 21/02
A61K 39/12

US Classification:

604 20, 536 2372, 514 44 R, 4242041, 4242021, 530300

Abstract:

Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV 6, HPV 11, HPV 33 and HPV58 E6 and E7. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HPV are disclosed.

US Patent:

20120093863, Apr 19, 2012

Filed:

Oct 20, 2011

Appl. No.:

13/278160

Inventors:

David B. WEINER - Merion PA, US
Krystle LANG - Philadelphia PA, US
Jian YAN - Havertown PA, US
Ruxandra DRAGHIA-AKLI - Brussels, BE
Amir S. KHAN - Narberth PA, US

International Classification:

A61K 39/29
A61K 31/711
C12N 15/63
A61K 38/16
A61P 31/14
C12N 15/51
C07K 14/18

US Classification:

4242281, 536 2372, 514 44 R, 530350, 514 43, 4353201

Abstract:

Improved anti-HCV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HCV genotype 1a, including for example, NS4B, NS5A and NS5B. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HCV are disclosed.