Jian S Yu

US Patent:

20040077832, Apr 22, 2004

Filed:

Nov 12, 2003

Appl. No.:

10/450436

Inventors:

Jian Yu - Pittsburgh PA, US
Kenneth Kinzler - Bel Air MD, US
Bert Vogelstein - Baltimore MD, US

International Classification:

A61K048/00
A61K038/17
C07K014/47
C12Q001/68
G01N033/574
C07H021/04

US Classification:

530/350000, 435/007230, 435/069100, 435/320100, 435/325000, 514/012000, 514/044000, 536/023500, 435/006000

Abstract:

Through global profiling of genes that were expressed soon after p53 expression, we identified a gene termed (JFY1). The protein encoded by (JFY1) was found to be exclusively mitochondrial and to bind to Bcl-2 and Bcl-Xthrough a BH3 domain. Exogenous expression of (JFY1) resulted in an extremely rapid and profound apoptosis that occurred much earlier than that resulting from exogenous expression of p53. Based on its unique expression patterns, p53-dependence, and biochemical properties,(JFY1) is likely to be a direct mediator of p53-associated apoptosis.

US Patent:

20190091768, Mar 28, 2019

Filed:

Sep 27, 2017

Appl. No.:

15/716664

Inventors:

- Adelphi MD, US
Jian H. Yu - Belcamp MD, US
Jeffrey Zabinski - Havre de Grace MD, US

International Classification:

B22F 3/105
C23C 24/08

Abstract:

Rapid additive sintering of materials using electric fields includes a pair of electrodes including a first and second electrode, a power supply operatively connected to the pair of electrodes, and an area in between the pair of electrodes that holds a material. The first electrode is configured for flash sintering the material. The first electrode may be movable and may include a stylus. The material may include powder and may include any of metallic and ceramic material. Multiple layers of materials may be flash sintered by the first electrode. The first electrode may generate an electric field between the first electrode and the material causes the flash sintering. A nozzle may supply the material at variable speeds. The first electrode may be configured to move at variable speeds and in variable directions. The flash sintering may occur at an electric field between 10-50000 V/cm and an electric current between 0-30A.