Jian Zheng

US Patent:

20060216699, Sep 28, 2006

Filed:

Jan 26, 2006

Appl. No.:

11/341363

Inventors:

Robert De Leys - Three Bridges NJ, US
Jian Zheng - Raritan NJ, US

International Classification:

C12Q 1/70
C07K 14/16
C07H 21/02
C12N 15/867

US Classification:

435005000, 435069300, 435456000, 435325000, 530324000, 530326000, 536023720, 530350000

Abstract:

This invention relates to peptides and their preparation. The peptides each have a sequence that corresponds to the immunodominant region of the HIV-1 group O gp41 envelope protein. The sequence is characterized in that it does not correspond to any known naturally occurring group O sequence or variant. Furthermore, the peptide binds anti-HIV-1 group O antibodies. There are several uses for the peptides, including the detection of antibodies produced in response to HIV-1 group O infection. The peptides may also be incorporated in mosaics and expressed recombinantly.

US Patent:

61499102, Nov 21, 2000

Filed:

Nov 4, 1999

Appl. No.:

9/433428

Inventors:

Robert De Leys - Three Bridges NJ
Jian Zheng - Raritan NJ

Assignee:

Ortho-Clinical Diagnostics, Inc. - Rochester NY

International Classification:

A61K 3921
A61K 3900
A61K 3938
A61K 3912
A61K 3800

US Classification:

4241881

Abstract:

This invention relates to peptides and their preparation. The peptides each have a sequence that corresponds to the immunodominant region of the HIV-1 group O gp41 envelope protein. The sequence is characterized in that it does not correspond to any known naturally occurring group O sequence or variant. Furthermore, the peptide binds anti-HIV-1 group O antibodies. There are several uses for the peptides, including the detection of antibodies produced in response to HIV-1 group O infection. The peptides may also be incorporated in mosaics and expressed recombinantly.