Jian Ping Zheng

US Patent:

7067247, Jun 27, 2006

Filed:

Mar 30, 2001

Appl. No.:

09/823077

Inventors:

Jian Zheng - Raritan NJ, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Rochester NY

International Classification:

C07K 14/02

US Classification:

435 5, 530820, 530826, 530806, 530350, 4241851, 4241861, 4241891, 536 231, 536 237, 536 2372

Abstract:

We isolated and characterized a new surface mutant of the hepatitis B virus surface antigen (HBsAg). The mutant was isolated from a symptomatic patient with Down's syndrome who was found to be persistently positive for both for HBsAg and anti-HBs Antibody (Ab) with an equally long-lasting anti-HB core (c) IgM Ab.

US Patent:

7399603, Jul 15, 2008

Filed:

Dec 18, 2003

Appl. No.:

10/740025

Inventors:

Jian Zheng - Raritan NJ, US
Steve Stanley Alexander - Flemington NJ, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Rochester NY

International Classification:

G01N 33/68

US Classification:

435 792, 435 693

Abstract:

In the present invention, we described the use of anti-DNA antibody for the detection of prions and diagnosis of Transmissible Spongiform Encephalopathies (TSE) diseases in animals and humans.

US Patent:

7482172, Jan 27, 2009

Filed:

Sep 19, 2005

Appl. No.:

11/229960

Inventors:

Jian Zheng - Raritan NJ, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Raritan NJ

International Classification:

G01N 33/543
G01N 33/566

US Classification:

436518, 436501

Abstract:

The aim of the present invention is to provide a non-intrusive way to isolate, concentrate and monitor the TSE disease-related pathogenic prion protein. The invention described several peptides and their ability to capture PrPfrom brain homogenate of prion disease infected animal and human. These eight peptides do not capture cellular prion protein from individual with no prion disease.

US Patent:

7807386, Oct 5, 2010

Filed:

Jan 22, 2009

Appl. No.:

12/357888

Inventors:

Jian Zheng - Raritan NJ, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Raritan NJ

International Classification:

G01N 33/53
G01N 33/543
G01N 33/566
C07K 14/00

US Classification:

435 71, 436501, 436518, 530300

Abstract:

The aim of the present invention is to provide a non-intrusive way to isolate, concentrate and monitor the TSE disease-related pathogenic prion protein. The invention described several peptides and their ability to capture PrPfrom brain homogenate of prion disease infected animal and human. These eight peptides do not capture cellular prion protein from individual with no prion disease.

US Patent:

7889674, Feb 15, 2011

Filed:

Aug 8, 2005

Appl. No.:

11/198168

Inventors:

Jong-hun Park - Suwon-si, KR
Jian liang Zheng - New York NY, US
Myung-jong Lee - New York NY, US

Assignee:

Samsung Electronics Co., Ltd. - Suwon-si
City University of New York - New York NY

International Classification:

H04L 12/28

US Classification:

370254

Abstract:

An address assigning method in a ZigBee network environment formed of a plurality of devices (or nodes), includes: linking the plurality of nodes in a cluster-tree structure; requesting desirable address blocks from a lowest level to a second highest level of the tree ancestor nodes desirable address blocks, respectively; and assigning the desired address blocks to descendents using a top-down procedure.

US Patent:

20060269953, Nov 30, 2006

Filed:

May 25, 2006

Appl. No.:

11/440977

Inventors:

Jian Zheng - Raritan NJ, US

International Classification:

C12Q 1/70
C12Q 1/68

US Classification:

435006000, 435005000

Abstract:

We isolated and characterized a new surface mutant of the hepatitis B virus surface antigen (HBsAg). The mutant was isolated from a symptomatic patient with Down's syndrome who was found to be persistently positive for both HBsAg and anti-HBs Antibody (Ab) with an equally long-lasting anti-HB core (c) IgM Ab.

US Patent:

20090104181, Apr 23, 2009

Filed:

Jul 14, 2008

Appl. No.:

12/172787

Inventors:

Jian Zheng - Raritan NJ, US
Steve Stanley Alexander - Flemington NJ, US

International Classification:

A61K 39/395
G01N 33/53

US Classification:

4241301, 435 78

Abstract:

In the present invention, we described the use of anti-DNA antibody for the detection of prions and diagnosis of Transmissible Spongiform Encephalopathies (TSE) diseases in animals and humans.

US Patent:

20100297607, Nov 25, 2010

Filed:

May 20, 2009

Appl. No.:

12/469568

Inventors:

Jian Zheng - Raritan NJ, US
Jianping Yang - Phillipsburg NJ, US

International Classification:

C12Q 1/70

US Classification:

435 5

Abstract:

The present invention is directed to combination immunoassays, reagents and kits for simultaneous detection of HCV antigens and anti-HCV antibodies in a sample. The combination immunoassays of the present invention employ a non-ionic detergent that effectively exposes or releases the HCV core antigen from virions in a sample without interfering with the performance of other reagents such as the capture of anti-HCV antibodies by recombinant HCV antigens.