Jian Yun Zheng

US Patent:

7067247, Jun 27, 2006

Filed:

Mar 30, 2001

Appl. No.:

09/823077

Inventors:

Jian Zheng - Raritan NJ, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Rochester NY

International Classification:

C07K 14/02

US Classification:

435 5, 530820, 530826, 530806, 530350, 4241851, 4241861, 4241891, 536 231, 536 237, 536 2372

Abstract:

We isolated and characterized a new surface mutant of the hepatitis B virus surface antigen (HBsAg). The mutant was isolated from a symptomatic patient with Down's syndrome who was found to be persistently positive for both for HBsAg and anti-HBs Antibody (Ab) with an equally long-lasting anti-HB core (c) IgM Ab.

US Patent:

7399603, Jul 15, 2008

Filed:

Dec 18, 2003

Appl. No.:

10/740025

Inventors:

Jian Zheng - Raritan NJ, US
Steve Stanley Alexander - Flemington NJ, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Rochester NY

International Classification:

G01N 33/68

US Classification:

435 792, 435 693

Abstract:

In the present invention, we described the use of anti-DNA antibody for the detection of prions and diagnosis of Transmissible Spongiform Encephalopathies (TSE) diseases in animals and humans.

US Patent:

7482172, Jan 27, 2009

Filed:

Sep 19, 2005

Appl. No.:

11/229960

Inventors:

Jian Zheng - Raritan NJ, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Raritan NJ

International Classification:

G01N 33/543
G01N 33/566

US Classification:

436518, 436501

Abstract:

The aim of the present invention is to provide a non-intrusive way to isolate, concentrate and monitor the TSE disease-related pathogenic prion protein. The invention described several peptides and their ability to capture PrPfrom brain homogenate of prion disease infected animal and human. These eight peptides do not capture cellular prion protein from individual with no prion disease.

US Patent:

7807386, Oct 5, 2010

Filed:

Jan 22, 2009

Appl. No.:

12/357888

Inventors:

Jian Zheng - Raritan NJ, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Raritan NJ

International Classification:

G01N 33/53
G01N 33/543
G01N 33/566
C07K 14/00

US Classification:

435 71, 436501, 436518, 530300

Abstract:

The aim of the present invention is to provide a non-intrusive way to isolate, concentrate and monitor the TSE disease-related pathogenic prion protein. The invention described several peptides and their ability to capture PrPfrom brain homogenate of prion disease infected animal and human. These eight peptides do not capture cellular prion protein from individual with no prion disease.

US Patent:

7889674, Feb 15, 2011

Filed:

Aug 8, 2005

Appl. No.:

11/198168

Inventors:

Jong-hun Park - Suwon-si, KR
Jian liang Zheng - New York NY, US
Myung-jong Lee - New York NY, US

Assignee:

Samsung Electronics Co., Ltd. - Suwon-si
City University of New York - New York NY

International Classification:

H04L 12/28

US Classification:

370254

Abstract:

An address assigning method in a ZigBee network environment formed of a plurality of devices (or nodes), includes: linking the plurality of nodes in a cluster-tree structure; requesting desirable address blocks from a lowest level to a second highest level of the tree ancestor nodes desirable address blocks, respectively; and assigning the desired address blocks to descendents using a top-down procedure.

US Patent:

20060216699, Sep 28, 2006

Filed:

Jan 26, 2006

Appl. No.:

11/341363

Inventors:

Robert De Leys - Three Bridges NJ, US
Jian Zheng - Raritan NJ, US

International Classification:

C12Q 1/70
C07K 14/16
C07H 21/02
C12N 15/867

US Classification:

435005000, 435069300, 435456000, 435325000, 530324000, 530326000, 536023720, 530350000

Abstract:

This invention relates to peptides and their preparation. The peptides each have a sequence that corresponds to the immunodominant region of the HIV-1 group O gp41 envelope protein. The sequence is characterized in that it does not correspond to any known naturally occurring group O sequence or variant. Furthermore, the peptide binds anti-HIV-1 group O antibodies. There are several uses for the peptides, including the detection of antibodies produced in response to HIV-1 group O infection. The peptides may also be incorporated in mosaics and expressed recombinantly.

US Patent:

20060269953, Nov 30, 2006

Filed:

May 25, 2006

Appl. No.:

11/440977

Inventors:

Jian Zheng - Raritan NJ, US

International Classification:

C12Q 1/70
C12Q 1/68

US Classification:

435006000, 435005000

Abstract:

We isolated and characterized a new surface mutant of the hepatitis B virus surface antigen (HBsAg). The mutant was isolated from a symptomatic patient with Down's syndrome who was found to be persistently positive for both HBsAg and anti-HBs Antibody (Ab) with an equally long-lasting anti-HB core (c) IgM Ab.

US Patent:

20090104181, Apr 23, 2009

Filed:

Jul 14, 2008

Appl. No.:

12/172787

Inventors:

Jian Zheng - Raritan NJ, US
Steve Stanley Alexander - Flemington NJ, US

International Classification:

A61K 39/395
G01N 33/53

US Classification:

4241301, 435 78

Abstract:

In the present invention, we described the use of anti-DNA antibody for the detection of prions and diagnosis of Transmissible Spongiform Encephalopathies (TSE) diseases in animals and humans.