Arthur G. Taveras - Denville NJ Ronald J. Doll - Maplewood NJ Alan B. Cooper - West Caldwell NJ Johan A. Ferreira - Bensalem PA Timothy Guzi - Chatham NJ Dinanath F. Rane - Morganville NJ Viyyoor M. Girijavallabhan - Parsippany NJ Cynthia J. Aki - Rutherford NJ Jianping Chao - Summit NJ Carmen Alvarez - Roselle Park NJ Joseph M. Kelly - Parlin NJ Tarik Lalwani - Philadelphia PA Jagdish A. Desai - Spotswood NJ James J-S Wang - Westfield NJ
Disclosed are compounds of the formula: wherein R represents an imidazole ring; R represents a carbamate, urea, amide or sulfonamide group; R represents H when the alkyl chain between the amide group and the R imidazole group is substituted, or R represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R is H, and the alkyl chain between the amide group and the R imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
Alan B. Cooper - West Caldwell NJ Ronald J. Doll - Maplewood NJ Johan A. Ferreira - Bensalem PA Ashit Ganguly - Upper Montclair NJ Viyyoor M. Girijavallabhan - Parsippany NJ Arthur G. Taveras - Denville NJ Jianping Chao - Summit NJ John J. Baldwin - Gwynedd Valley PA Chia-Yu Huang - Plainsboro NJ Ge Li - Lawrenceville NJ
Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
Arthur G. Taveras - Denville NJ Ronald J. Doll - Maplewood NJ Alan B. Cooper - West Caldwell NJ Johan A. Ferreira - Bensalem PA Timothy Guzi - Chatham NJ Alan K. Mallams - Hackettstown NJ Dinanath F. Rane - Morganville NJ Viyyoor M. Girijavallabhan - Parsippany NJ Adriano Afonso - West Caldwell NJ Cynthia J. Aki - Rutherford NJ Jianping Chao - Summit NJ Carmen Alvarez - Roselle Park NJ Joseph M. Kelly - Parlin NJ Tarik Lalwani - Philadelphia PA Jagdish A. Desai - Spotswood NJ James J-S Wang - Westfield NJ Jay Weinstein - Upper Montclair NJ
Disclosed are compounds of the formula: wherein R represents an imidazole ring; R represents a carbamate, urea, amide or sulfonamide group; R represents H when the alkyl chain between the amide group and the R imidazole group is substituted, or R represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R is H, and the alkyl chain between the amide group and the R imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
Timothy Guzi - Chatham NJ Dinanath F. Rane - Morganville NJ Alan K. Mallams - Hackettstown NJ Alan B. Cooper - West Caldwell NJ Ronald J. Doll - Maplewood NJ Viyyoor M. Girijavallabhan - Parsippany NJ Arthur G. Taveras - Denville NJ Corey Strickland - North Plainfield NJ Joseph M. Kelly - Parlin NJ Jianping Chao - Summit NJ
Disclosed are compounds of the formula: wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
3,4-Di-Substituted Pyridazinediones As Cxc Chemokine Receptor Antagonists
Arthur G. Taveras - Denville NJ, US Michael Dwyer - Scotch Plains NJ, US Jianping Chao - Summit NJ, US John J. Baldwin - Gwynedd Valley PA, US J. Robert Merritt - Ewing NJ, US Ge Li - Shanghai, CN Jianhua Chao - Pompton Lakes NJ, US Younong Yu - Piscataway NJ, US
Assignee:
Schering Corporation - Kenilworth NJ Pharmacopeia Drug Discovery, Inc. - Princeton NJ
Disclosed are compounds of the formula (I)
or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
3,4-Di-Substituted Maleimide Compounds As Cxc Chemokine Receptor Antagonists
Arthur G. Taveras - Denville NJ, US Michael Dwyer - Scotch Plains NJ, US Johan A. Ferreira - Bethlehem PA, US Viyyoor M. Girijavallabhan - Parsippany NJ, US Jianping Chao - Summit NJ, US John J. Baldwin - Gwynedd Valley PA, US J. Robert Merritt - Ewing NJ, US Ge Li - Shanghai, CN
Assignee:
Schering Corporation - Kenilworth NJ Pharmacopeia Drug Discovery, Inc. - Cranbury NJ
International Classification:
A61K031/4015 C07D409/12
US Classification:
514425, 548517, 548527, 548406, 548204, 514422
Abstract:
Disclosed are compounds of the formula (I)
or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
3,4-Di-Substituted Cyclobutene-1,2-Diones As Cxc-Chemokine Receptor Ligands
Arthur G. Taveras - Denville NJ, US Cynthia J. Aki - Livingston NJ, US Richard W. Bond - Union NJ, US Jianping Chao - Summit NJ, US Michael Dwyer - Scotch Plains NJ, US Johan A. Ferreira - Bethlehem PA, US Jianhua Chao - Pompton Lakes NJ, US Younong Yu - Scotch Plains NJ, US John J. Baldwin - Gwynedd Valley PA, US Bernd Kaiser - Wallingford CT, US Ge Li - Shanghai, CN J. Robert Merritt - Ewing NJ, US Purakkattle J. Biju - Scotch Plains NJ, US Laura L. Rokosz - Union NJ, US James P. Jakway - Bridgewater NJ, US Gaifa Lai - Edison NJ, US Minglang Wu - Monmouth Junction NJ, US Evan A. Hecker - Austin TX, US Daniel Lundell - Flemington NJ, US Jay S. Fine - Bloomfield NJ, US
Assignee:
Schering Corporation - Kenilworth NJ Pharmacopeia Drug Discovery, Inc. - Cranbury NJ
Arthur G. Taveras - Southborough MA, US Cynthia J. Aki - Livingston NJ, US Richard W. Bond - Union NJ, US Jianping Chao - Summit NJ, US Michael Dwyer - Scotch Plains NJ, US Johan A. Ferreira - Bensalem PA, US Jianhua Chao - Pompton Lakes NJ, US Younong Yu - East Brunswick NJ, US John J. Baldwin - Gwynedd Valley PA, US Bernd Kaiser - Plainsboro NJ, US Ge Li - Shanghai, CN J. Robert Merritt - Ewing NJ, US Purakkattle J. Biju - Piscataway NJ, US Laura L. Rokosz - Union NJ, US