Jill A Fortney

US Patent:

20100229251, Sep 9, 2010

Filed:

Oct 2, 2008

Appl. No.:

12/681196

Inventors:

Jill A. Fortney - Westerville OH, US
Philip F. Binkley - Columbus OH, US
Paul M. Janssen - Dublin OH, US
Tessily A. Mays - Pataskala OH, US
Jamie L. Sanford - Worthington OH, US

Assignee:

THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION - Columbus OH

International Classification:

A01K 67/00
G01N 33/68
A61K 31/00
C12Q 1/02
G01N 33/53
A61P 9/00

US Classification:

800 9, 436 86, 514789, 435 29, 435 71

Abstract:

The present invention provides a method for diagnosis end-stage cardiomyopathy includes measuring expression of claudin-5 levels in a patient suspected of suffering from end-stage cardiomyopathy as well as a method for treating end-stage cardiomyopathy includes administering an effective amount of a composition effectively upregulates the claudin-5 or inhibits degradation of claudin-5