Jill Z Mcfadden

US Patent:

20060241177, Oct 26, 2006

Filed:

Jul 1, 2003

Appl. No.:

10/519804

Inventors:

Susan Medghalchi - Baltimore MD, US
Jagan Thupari - Baltimore MD, US
Craig Townsend - Baltimore MD, US
Jill McFadden - Baltimore MD, US

International Classification:

A61K 31/365
C07D 305/12

US Classification:

514471000, 514473000, 549321000

Abstract:

Pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula IX: R═H, or C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, ═CHR, —C(O)OR, —C(O)R, —CHC(O)OR, CHC(O)NHR, where Ris H or C-Calkyl, cycloalkyl, or alkenyl; R═C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl; X═—OR, or NHR, Where Ris H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, the Rgroup optionally containing a carbonyl group, a carboxyl group, a carboxyamide group, an alcohol group, or an ether group, the Rgroup further optionally containing one or more halogen atoms; with the proviso that when Ris ═CH, then Xis not OH. Also disclosed are compounds within the scope of the formula IX, as well as uses of the pharmaceutical compositions for weight loss, anti-microbial and anti-cancer applications, inhibition of fatty acid synthase and neuropeptide-Y, and the stimulation of the activity of carnitine palmitoyl transferase-1.

US Patent:

20060247302, Nov 2, 2006

Filed:

Jul 9, 2003

Appl. No.:

10/520505

Inventors:

Francis Kuhajda - Baltimore MD, US
Susan Medghalchi - Baltimore MD, US
Jill McFadden - Baltimore MD, US
Jagan Thupari - Baltimore MD, US

Assignee:

FASgen, Inc. - Baltimore MD
Johns Hopkins University - Baltimore MD

International Classification:

A61K 31/381
C07D 333/32

US Classification:

514445000, 549062000

Abstract:

A pharmaceutical composition comprising a phamaceurtical diluent and a compound of formula IV wherein R═H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, —CHOR, —C(O)R, —CO(O)R, —C(O)NRR, —CHC(O)R, or —CHC(O)NHR, where Rand Rare each independently H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing one or more halogen atoms. R═—OH, —OR, —OCHC(O)R, —OCHC(O)NHR, —OC(O)R, —OC(O)OR, —OC(O)NHNH—R, or —OC(O)NRR, where Rand Rare each independently H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, and where Rand Rcan each optionally contain halogen atoms; Rand R, the same or different from each other, are C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. Methods of using such formulations for the treatment of cancer, to effect weight loss, to treat microbially-based infections, to inhibit neuropeptide-Y and/or fatty acid synthase, and to stimulate CPT-1.

US Patent:

20100029752, Feb 4, 2010

Filed:

Jul 26, 2006

Appl. No.:

12/309418

Inventors:

Francis P. Kuhajda - Baltimore MD, US
Craig A. Townsend - Baltimore MD, US
Susan M. Medghalchi - Baltimore MD, US
Jill M. McFadden - Baltimore MD, US

International Classification:

A61K 31/381
C07D 307/34
C07D 307/26
A61P 35/00

US Classification:

514444, 549479, 549473, 514445

Abstract:

A pharmaceutical composition containing a pharmaceutical diluent and a compound of formula II: wherein: R═H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, —C(O)R, where Ris H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms, or —OH, —ORor —NR, where Ris H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms; R=—OR, —NR, —NH—NH—Rwhere Ris H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, allyl, or alkylaryl, optionally containing halogen atoms; R═H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, or —CHC(O)R, where Ris ORand NR, where R═H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, allyl, or alkylaryl and can optionally contain halogen atoms. Also included in the invention are methods of using the pharmaceutical compositions and the chemical compounds used in the compositions.

US Patent:

20100029761, Feb 4, 2010

Filed:

Jul 26, 2006

Appl. No.:

12/309419

Inventors:

Francis P. Kuhajda - Baltimore MD, US
Craig A. Townsend - Baltimore MD, US
Susan M. Medghalchi - Baltimore MD, US
Jill M. McFadden - Baltimore MD, US

International Classification:

A61K 31/341
C07D 307/04
C07D 307/26
A61P 3/04

US Classification:

514473, 549477

Abstract:

A pharmaceutical diluent and a compound of formula VI: wherein: R10=H, or C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms; R11=H3 or C]-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms; R12=H, or C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms, —C(O)R13, where R13 is H, Ci-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms, or —OH, —OR14 or —NR14, where R14 is H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing halogen atoms.

US Patent:

20100120901, May 13, 2010

Filed:

Jan 13, 2010

Appl. No.:

12/686691

Inventors:

Francis P. Kuhajda - Baltimore MD, US
Susan M. Medghalchi - Baltimore MD, US
Jill M. McFadden - Baltimore MD, US
Jagan Thupari - Baltimore MD, US
Craig A. Townsend - Baltimore MD, US

Assignee:

FASGEN,INC - Baltimore MD
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 31/381
C07D 333/32
A61P 3/00
A61P 31/00

US Classification:

514445, 549 62, 549 65, 549 66

Abstract:

A pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula IV wherein R=H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, —CHOR, —C(O)R, —CO(O)R, —C(O)NRR, —CHC(O)R, or —CHC(O)NHR, where Rand Rare each independently H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing one or more halogen atoms. R=—OH, —OR, —OCHC(O)R, —OCHC(O)NHR, —OC(O)R, —OC(O)OR, —OC(O)NHNH—R, or —OC(O)NRR, where Rand Rare each independently H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, and where Rand Rcan each optionally contain halogen atoms; Rand R, the same or different from each other, are C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. Methods of using such formulations for the treatment of cancer, to effect weight loss, to treat microbially-based infections, to inhibit neuropeptide-Y and/or fatty acid synthase, and to stimulate CPT-1.

US Patent:

20110288052, Nov 24, 2011

Filed:

Jun 2, 2009

Appl. No.:

12/995663

Inventors:

Craig A. Townsend - Baltimore MD, US
Kandasamy Subburaj - Baltimore MD, US
Jill Marie McFadden - Chapel Hill NC, US

International Classification:

C07D 333/32
C07D 409/12
C07D 413/12
A61K 31/5377
A61P 31/00
A61K 31/496
A61K 31/4535
A61P 35/04
A61P 3/04
A61K 31/381
A61K 31/69

US Classification:

514 64, 549 66, 514445, 514444, 549 60, 549 59, 544146, 5142315, 549 4, 544379, 51425213, 514326, 546213

Abstract:

The class compounds of the present invention may be represented by Formula (I), wherein X may be O, S, or N. Rand Rare independently either H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. Rand Rare independently either H, an aryl group, a heteroaryl group, and a heterocyclic ring group having 4 to 6 carbon atoms, wherein the aryl, heteroaryl, and heterocyclic moieties are optionally substituted with one or more of a first substitution group defined herein. In a further embodiment, Rand Ralong with the atoms and bonds to which they are attached, form an optionally substituted 5-7 membered ring having at least one nitrogen atom within the ring structure.