Jill M Ray

US Patent:

7115370, Oct 3, 2006

Filed:

Jun 5, 2002

Appl. No.:

10/164103

Inventors:

Jill M. Ray - Rockville MD, US
Teri Heiland - New Market MD, US
Indira Carey - Silver Spring MD, US

Assignee:

Capital Genomix, Inc. - Gaithersburg MD

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435 6, 435 912

Abstract:

The present invention is directed to a method of detecting gene expression and analysis of both known and unknown genes. In the method utilizing combinatorial oligonucleotide PCR™, no single molecular species of DNA gives rise to more than one fragment in a collection of products which are subsequently amplified and representative of each expressed gene. More specifically, the present invention improves known methods by eliminating the recovery of restriction fragments with two identical ends and furthermore regards amplification and isolation of the restriction fragment utilizing a labeled primer.

US Patent:

20030194707, Oct 16, 2003

Filed:

Apr 3, 2002

Appl. No.:

10/114929

Inventors:

Indira Carey - Silver Spring MD, US
Teri Heiland - New Market MD, US
Anna Smith - Gaithersburg MD, US
Jill Ray - Rockville MD, US

Assignee:

Capitol Genomix, Inc.

International Classification:

C12Q001/68
C07H021/02
C07H021/04

US Classification:

435/006000, 536/025400

Abstract:

The present invention is directed to methods and compositions wherein nucleic acids are associated with a solid phase that comprises a carboxylated substrate. In specific embodiments, precipitation of the nucleic acids occurs in the absence of salt.

US Patent:

20060026697, Feb 2, 2006

Filed:

May 18, 2005

Appl. No.:

11/132165

Inventors:

Bill Hearl - Damascus MD, US
Jill Ray - Rockville MD, US
Teri Heiland - New Market MD, US
David Grass - Princeton NJ, US

International Classification:

A01K 67/027

US Classification:

800006000, 800018000

Abstract:

The present disclosure is directed to novel methods for genetic immunization which utilize a eukaryote host with a non-eukaryotic expression system. Preferably the non-eukaryotic expression system is a bacteriophage RNA Polymerase, for example T7 RNA Polymerase, which is preferably expressed in specific tissue(s) of the host. Genetic immunization occurs when the eukaryote host is exposed to a polynucleotide construct encoding a specific immunogen operably linked to a promoter recognized by the non-eukaryotic expression system, which generates expression of the immunogen, thereby eliciting a humoral and/or cellular immune response in the host. The present disclosure is also directed to transgenic animals that express the non-eukaryotic expression system.

US Patent:

20060205004, Sep 14, 2006

Filed:

May 11, 2006

Appl. No.:

11/432199

Inventors:

Indira Carey - Silver Spring MD, US
Teri Heiland - New Market MD, US
Anna Smith - Gaithersburg MD, US
Jill Ray - Rockville MD, US

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435006000, 536025400

Abstract:

The present invention is directed to methods and compositions wherein nucleic acids are associated with a solid phase that comprises a carboxylated substrate. In specific embodiments, precipitation of the nucleic acids occurs in the absence of salt.