Jin Xian Lu

US Patent:

7405169, Jul 29, 2008

Filed:

Oct 4, 2006

Appl. No.:

11/543172

Inventors:

Jin Lu - North Wales PA, US

Assignee:

Rohm and Hass Company - Philadelphia PA

International Classification:

B32B 5/02
B32B 9/04

US Classification:

442154, 442157, 428446, 428447

Abstract:

Composite materials that contain formaldehyde-free, cured binder compositions are disclosed. Also disclosed are methods of making and using composite materials containing formaldehyde-free binder compositions.

US Patent:

7736650, Jun 15, 2010

Filed:

Dec 21, 2005

Appl. No.:

11/722281

Inventors:

Jin Lu - Boothwyn PA, US
Thomas Nesspor - Collegeville PA, US
Bernard Scallon - Wayne PA, US
Linda Snyder - Pottstown PA, US

Assignee:

Centocor, Inc. - Malvern PA

International Classification:

A61K 39/395
C07H 21/02
C07H 21/04
C12N 15/00
C12N 5/00
C12N 5/02
C12N 5/06
C12N 5/10
C12P 21/04

US Classification:

4241721, 536 231, 536 235, 4353201, 435325, 435 696

Abstract:

Antibody expression vectors and plasmids can incorporate various antibody gene portions for transcription of the antibody DNA and expression of the antibody in an appropriate host cell. The expression vectors and plasmids have restriction enzyme sites that facilitate ligation of antibody-encoding DNA into the vectors. The vectors incorporate enhancer and promoter sequences that can be varied to interact with transcription factors in the host cell and thereby control transcription of the antibody-encoding DNA. A kit can incorporate these vectors and plasmids.

US Patent:

7888117, Feb 15, 2011

Filed:

May 17, 2007

Appl. No.:

11/750053

Inventors:

Haimanti Dorai - Exton PA, US
Jin Lu - Boothwyn PA, US

International Classification:

C12N 5/00
C07K 14/00
C07H 21/04

US Classification:

435325, 530350, 536 235, 536 231

Abstract:

p-00010000Homo sapiens.

US Patent:

8361474, Jan 29, 2013

Filed:

Apr 13, 2010

Appl. No.:

12/759154

Inventors:

Jin Lu - Boothwyn PA, US
Thomas Nesspor - Collegeville PA, US
Bernard Scallon - Wayne PA, US
Linda Snyder - Pottstown PA, US

Assignee:

Centocor, Inc. - Malvern PA

International Classification:

A61K 39/395
C07H 21/02
C07H 21/04
C12N 15/00
C12N 5/00
C12N 5/02
C12N 5/10
C12P 21/04

US Classification:

4241721, 536 231, 536 235, 4353201, 435325, 435 696

Abstract:

Antibody expression vectors and plasmids can incorporate various antibody gene portions for transcription of the antibody DNA and expression of the antibody in an appropriate host cell. The expression vectors and plasmids have restriction enzyme sites that facilitate ligation of antibody-encoding DNA into the vectors. The vectors incorporate enhancer and promoter sequences that can be varied to interact with transcription factors in the host cell and thereby control transcription of the antibody-encoding DNA. A kit can incorporate these vectors and plasmids.

US Patent:

20050008638, Jan 13, 2005

Filed:

Jun 25, 2003

Appl. No.:

10/603313

Inventors:

Jin Lu - Boothwyn PA, US
Li Yan - Wayne PA, US
Chris Huang - Paoli PA, US
Marian Nakada - Malvern PA, US

International Classification:

C12Q001/68
C07H021/04
A61K039/395
C12N009/00
C07K016/40
C12P021/02
C12N005/06

US Classification:

424145100, 435006000, 536023200, 435069100, 435183000, 435320100, 435325000, 530388260

Abstract:

The present invention relates to at least one novel CNGH0005 polypeptides, antibodies, including isolated nucleic acids that encode at least one CNGH0005 polypeptide or antibody, CNGH0005 vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

US Patent:

20050033029, Feb 10, 2005

Filed:

Jun 21, 2004

Appl. No.:

10/872932

Inventors:

Jin Lu - Boothwyn PA, US

International Classification:

C07K016/00

US Classification:

530388100

Abstract:

The present invention relates to anti-target immunoglobulin derived proteins, including isolated nucleic acids that encode at least one anti-target Ig derived protein, target, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

US Patent:

20060088845, Apr 27, 2006

Filed:

Mar 28, 2005

Appl. No.:

11/091234

Inventors:

Jin Lu - Boothwyn PA, US

International Classification:

C12Q 1/68
G01N 33/53
G06F 19/00

US Classification:

435006000, 435007100, 702019000

Abstract:

The invention provides methods, computer programs, data and databases, computer readable media, computer systems, and/or apparatus that use, compare or generate data corresponding to at least one partial antibody or antibody fusion protein nucleic acid or amino acid sequence, on recordable media or in computer memory, such as engineered antibody or antibody fusion protein sequences that include any combination of partial antibody sequences, as well as comparisons between different human antibody partial or full sequences, wherein the present invention can be used, inter alia, for research, diagnostic and/or therapeutic products, methods and devices.

US Patent:

20100021477, Jan 28, 2010

Filed:

Aug 25, 2009

Appl. No.:

12/546850

Inventors:

Ping Tsui - Berwyn PA, US
Lei Shi - Radnor PA, US
Jin Lu - Radnor PA, US
John Wheeler - Radnor PA, US
Brian Whitaker - Radnor PA, US
Lionella Borozdina-Birch - San Diego CA, US
Juan C. Almagro - Radnor PA, US
Bernard Amegadzie - Radnor PA, US
Mark Tornetta - Radnor PA, US
Ramachandra Reddy - Radnor PA, US
David M. Knight - Radnor PA, US
Jinquan Luo - Radnor PA, US
Raymond W. Sweet - Radnor PA, US
Qiang Chen - San Diego CA, US

International Classification:

A61K 39/40
C12N 15/63
C12N 1/21
C07K 14/195
C07K 16/12
C40B 40/02
C40B 30/04

US Classification:

4241641, 4353201, 4352523, 530350, 5303871, 506 14, 506 9

Abstract:

Described and claimed herein are combinatorial synthetic Fab libraries displayed on a phage pIX protein. The libraries were built on scaffolds representing the most frequently used genes in human antibodies, which were diversified to mirror the variability of natural antibodies. After selection using a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. By a process called in-line maturation the affinity of some antibodies was improved up to one hundred-fold yielding low pM binders suitable for in vivo use. This work thus demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and lays the foundations for studies on the structure-function relationship of antibodies.