Jingchun C Liu

US Patent:

7482348, Jan 27, 2009

Filed:

Mar 15, 2006

Appl. No.:

11/376432

Inventors:

George Chiu - Bridgewater NJ, US
Shengjian Li - Belle Mead NJ, US
Peter J. Connolly - New Providence NJ, US
Virginia L. Pulito - Flemington NJ, US
Jingchun Liu - Three Bridges NJ, US
Steven A. Middleton - Flemington NJ, US

Assignee:

Janssen Pharmaceutica N.V.

International Classification:

A61K 31/496
C07D 213/74

US Classification:

51425312, 544360

Abstract:

The present invention relates to piperazine substituted cyclohexane-1,4-diamine compounds of Formula (I).

US Patent:

20060217419, Sep 28, 2006

Filed:

Mar 15, 2006

Appl. No.:

11/376348

Inventors:

George Chiu - Bridgewater NJ, US
Shengjian Li - Belle Mead NJ, US
Peter Connolly - New Providence NJ, US
Virginia Pulito - Flemington NJ, US
Jingchun Liu - Three Bridges NJ, US
Steven Middleton - Flemington NJ, US

International Classification:

A61K 31/454
A61K 31/445
C07D 401/02
C07D 211/26

US Classification:

514317000, 514326000, 546229000, 546207000

Abstract:

The present invention relates to piperidine substituted cyclohexane-1,4-diamine compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α/αadrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as method of treatments.