Jing Y Yang

US Patent:

7205329, Apr 17, 2007

Filed:

Jul 18, 2005

Appl. No.:

11/183626

Inventors:

G. Todd Milne - Brookline MA, US
Mark G. Currie - Sterling MA, US
John Jeffrey Talley - Somerville MA, US
Brian M. Cali - Arlington MA, US
Barbara Chen - Braintree MA, US
Craig Zimmerman - Topsfield MA, US
Jing Jing Yang - Boxborough MA, US

Assignee:

Microbia, Inc. - Cambridge MA

International Classification:

A61K 31/405
C07D 209/12

US Classification:

514415, 548469

Abstract:

Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.

US Patent:

7547767, Jun 16, 2009

Filed:

Nov 21, 2006

Appl. No.:

11/602865

Inventors:

Jing Yang - Ambler PA, US
George Heavner - Malvern PA, US
Robert Jordan - Thornton PA, US
Ray Sweet - Bala Cynwyd PA, US

Assignee:

Centocor Ortho Biotech Inc. - Horsham PA

International Classification:

C07K 16/46

US Classification:

5303881, 4241391, 5303871

Abstract:

The present invention provides novel proteins and peptides from the receptor binding region of human Growth Arrest Specific Gene 6 (Gas6) and antibodies, including specified portions or variants, specific for at least one such Gas6 peptide or fragment thereof. The aforesaid peptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-Gas6 antibodies. The invention also provides for the nucleic acids encoding such peptides and anti-Gas6 antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, including therapeutic formulations, administration and devices. Fifteen novel peptide sequences from the Gas6 G domain that are implicated in Gas6 interactions with its receptors are identified, isolated, and synthesized so as to allow generation of anti-Gas6 antibodies. The peptide sequences include three ESTs that encompass regions predicted to contribute to receptor binding or that can raise anti-Gas6 antibodies. This invention provides for such antibodies to be used in modulating or treating at least one Gas6-related disease in a cell, tissue, organ, animal, or patient.

US Patent:

7560112, Jul 14, 2009

Filed:

Apr 28, 2006

Appl. No.:

11/413561

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Applied Molecular Evolution, Inc. - San Diego CA
Centocor Ortho Biotech Inc. - Malvern PA

International Classification:

A61K 39/395
C07K 16/24
C12N 5/12

US Classification:

4241391, 53038823, 435326

Abstract:

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

7833755, Nov 16, 2010

Filed:

May 22, 2009

Appl. No.:

12/470753

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

International Classification:

C12N 5/10
C12N 15/13
C12N 15/63

US Classification:

435 696, 536 2353, 4352523, 4353201, 435325

Abstract:

Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

8067003, Nov 29, 2011

Filed:

Oct 8, 2010

Appl. No.:

12/901200

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Centocor, Inc. - Malvern PA
Applied Molecular Evolution, Inc. - San Diego CA

International Classification:

A61K 39/395

US Classification:

4241451, 4241301, 4241411

Abstract:

Anti-IL-6 antibodies are used to treat IL-6 related conditions, such as rheumatoid arthritis, osteoarthritis, osteolysis, aseptic loosening of orthopedic implants, systemic lupus erythematosus, cutaneous lupus erythematosus, lupus nephritis, type 2 diabetes mellitus, chronic obstructive pulmonary disease, and renal cell carcinoma.

US Patent:

8088590, Jan 3, 2012

Filed:

Dec 28, 2006

Appl. No.:

11/646706

Inventors:

Sendurai Mani - Cambridge MA, US
Jing Yang - Cambridge MA, US
Robert A. Weinberg - Brookline MA, US

Assignee:

Whiteland Institute for Biomedical Research - Cambridge MA

International Classification:

G01N 33/574
C12Q 1/68

US Classification:

435 723, 435 6, 435 71

Abstract:

The invention relates to methods and compositions for inhibiting metastasis, such as by inhibiting FOXC2 expression or activity. The invention further relates to methods of prognosticating, diagnosing, and assisting in the diagnosis of metastasis in an individual, or of determining the metastatic potential of a tumor. The invention further relates to methods of identifying agents which inhibit metastasis.

US Patent:

8226611, Jul 24, 2012

Filed:

Oct 27, 2011

Appl. No.:

13/283177

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Janssen Biotech, Inc. - Horsham PA
Applied Molecular Evolution - San Diego CA

International Classification:

A61M 37/00
A61M 5/32
A61K 39/395
C07K 16/24

US Classification:

604143, 604198, 4241391, 53038823

Abstract:

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

RE43672, Sep 18, 2012

Filed:

Jul 8, 2011

Appl. No.:

13/178998

Inventors:

Yan Chan - Radnor PA, US
Debra Gardner - Radnor PA, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Berwyn PA, US
Bailin Liang - Jacksonville FL, US
David J. Shealy - Radnor PA, US
Xiao-yu R. Song - Somerville NJ, US
Raymond W. Sweet - Radnor PA, US
Susan H. Tam - Radnor PA, US
Sheng-Jiun Wu - Radnor PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Janssen Biotech, Inc. - Horsham PA
Applied Molecular Evolution - San Diego CA

International Classification:

A61K 39/395
C07K 16/24
C12N 5/12

US Classification:

4241391, 53038823, 435326

Abstract:

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.