Jing C Yang

US Patent:

7547767, Jun 16, 2009

Filed:

Nov 21, 2006

Appl. No.:

11/602865

Inventors:

Jing Yang - Ambler PA, US
George Heavner - Malvern PA, US
Robert Jordan - Thornton PA, US
Ray Sweet - Bala Cynwyd PA, US

Assignee:

Centocor Ortho Biotech Inc. - Horsham PA

International Classification:

C07K 16/46

US Classification:

5303881, 4241391, 5303871

Abstract:

The present invention provides novel proteins and peptides from the receptor binding region of human Growth Arrest Specific Gene 6 (Gas6) and antibodies, including specified portions or variants, specific for at least one such Gas6 peptide or fragment thereof. The aforesaid peptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-Gas6 antibodies. The invention also provides for the nucleic acids encoding such peptides and anti-Gas6 antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, including therapeutic formulations, administration and devices. Fifteen novel peptide sequences from the Gas6 G domain that are implicated in Gas6 interactions with its receptors are identified, isolated, and synthesized so as to allow generation of anti-Gas6 antibodies. The peptide sequences include three ESTs that encompass regions predicted to contribute to receptor binding or that can raise anti-Gas6 antibodies. This invention provides for such antibodies to be used in modulating or treating at least one Gas6-related disease in a cell, tissue, organ, animal, or patient.

US Patent:

7560112, Jul 14, 2009

Filed:

Apr 28, 2006

Appl. No.:

11/413561

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Applied Molecular Evolution, Inc. - San Diego CA
Centocor Ortho Biotech Inc. - Malvern PA

International Classification:

A61K 39/395
C07K 16/24
C12N 5/12

US Classification:

4241391, 53038823, 435326

Abstract:

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

7833755, Nov 16, 2010

Filed:

May 22, 2009

Appl. No.:

12/470753

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

International Classification:

C12N 5/10
C12N 15/13
C12N 15/63

US Classification:

435 696, 536 2353, 4352523, 4353201, 435325

Abstract:

Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

8067003, Nov 29, 2011

Filed:

Oct 8, 2010

Appl. No.:

12/901200

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Centocor, Inc. - Malvern PA
Applied Molecular Evolution, Inc. - San Diego CA

International Classification:

A61K 39/395

US Classification:

4241451, 4241301, 4241411

Abstract:

Anti-IL-6 antibodies are used to treat IL-6 related conditions, such as rheumatoid arthritis, osteoarthritis, osteolysis, aseptic loosening of orthopedic implants, systemic lupus erythematosus, cutaneous lupus erythematosus, lupus nephritis, type 2 diabetes mellitus, chronic obstructive pulmonary disease, and renal cell carcinoma.

US Patent:

8226611, Jul 24, 2012

Filed:

Oct 27, 2011

Appl. No.:

13/283177

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Janssen Biotech, Inc. - Horsham PA
Applied Molecular Evolution - San Diego CA

International Classification:

A61M 37/00
A61M 5/32
A61K 39/395
C07K 16/24

US Classification:

604143, 604198, 4241391, 53038823

Abstract:

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

RE43672, Sep 18, 2012

Filed:

Jul 8, 2011

Appl. No.:

13/178998

Inventors:

Yan Chan - Radnor PA, US
Debra Gardner - Radnor PA, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Berwyn PA, US
Bailin Liang - Jacksonville FL, US
David J. Shealy - Radnor PA, US
Xiao-yu R. Song - Somerville NJ, US
Raymond W. Sweet - Radnor PA, US
Susan H. Tam - Radnor PA, US
Sheng-Jiun Wu - Radnor PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Janssen Biotech, Inc. - Horsham PA
Applied Molecular Evolution - San Diego CA

International Classification:

A61K 39/395
C07K 16/24
C12N 5/12

US Classification:

4241391, 53038823, 435326

Abstract:

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

8623362, Jan 7, 2014

Filed:

Jun 15, 2012

Appl. No.:

13/524684

Inventors:

Yan Chen - Wayne PA, US
Debra Gardner - Bear DE, US
David M. Knight - Berwyn PA, US
Michael W. Lark - Devon PA, US
Bailin Liang - Gilbertsville PA, US
David J. Shealy - Downingtown PA, US
Xiao-Yu R. Song - West Chester PA, US
Raymond W. Sweet - Bryn Mawr PA, US
Susan H. Tam - Boothwyn PA, US
Sheng-Jiun Wu - Broomall PA, US
Jing Yang - Ambler PA, US
David Matthew Marquis - Encinitas CA, US
Eric Michael Smith - San Diego CA, US
Alain Philippe Vasserot - Carlsbad CA, US

Assignee:

Janssen Biotech, Inc. - Horsham PA
Applied Molecular Evolution - San Diego CA

International Classification:

A61K 39/395

US Classification:

4241391, 4241411

Abstract:

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

US Patent:

20040157774, Aug 12, 2004

Filed:

Sep 24, 2003

Appl. No.:

10/671054

Inventors:

Jing Yang - Ambler PA, US
Cailin Chen - New Hope PA, US
Bing Hu - Media PA, US
Patricia Andrade-Gordon - Doylestown PA, US
Robert Jordan - Thornton PA, US

International Classification:

A61K038/17
C07K014/705

US Classification:

514/012000, 530/350000

Abstract:

The present invention provides epitope-tagged mammalian recombinant Growth Arrest Specific Gene 6 (Gas6) proteins or polypeptides that retain their biological activity of Gas6, including a novel method of generating and purifying the aforesaid proteins or polypeptides. Such biolgically active eptitope-tagged Gas6 proteins or polypeptides can be used when the presence of Gas6 is required and/or when Gas6 antagonists and receptors need to be identified. Prior to being expressed from a mammalian cell, the recombinant Gas6 protein or polypeptide is tagged with either Flag or polyhistidine to the C-terminus. After expression, the protein or polypeptide is purified in a single step affinity purification using either anti-Flag antibody resin or nickle resin. The purified epitope-tagged mammalian recombinant Gas6 protein or polypeptide maintains its biological activity and can be used thereafter.