Jinjin Ma

US Patent:

20080241209, Oct 2, 2008

Filed:

Feb 4, 2008

Appl. No.:

12/025151

Inventors:

Ellen M. Arruda - Ann Arbor MI, US
Lisa M. Larkin - Ann Arbor MI, US
Michael Smietana - Orion MI, US
Jinjin Ma - Ann Arbor MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

A61F 2/28

US Classification:

424423

Abstract:

A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.

US Patent:

20140243979, Aug 28, 2014

Filed:

May 1, 2014

Appl. No.:

14/267439

Inventors:

- Ann Arbor MI, US
Lisa M. Larkin - Ann Arbor MI, US
Michael Smietana - Orion MI, US
Jinjin Ma - Ann Arbor MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

A61L 27/36
A61F 2/08
A61F 2/28

US Classification:

623 1317, 623 2363, 435395

Abstract:

A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.