Jinjin Ma

US Patent:

2008024, Oct 2, 2008

Filed:

Feb 4, 2008

Appl. No.:

12/025151

Inventors:

Ellen M. Arruda - Ann Arbor MI,
Lisa M. Larkin - Ann Arbor MI,
Michael Smietana - Orion MI,
Jinjin Ma - Ann Arbor MI,

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

A61F 2/28

US Classification:

424423

Abstract:

A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.