Ellen M. Arruda - Ann Arbor MI, Lisa M. Larkin - Ann Arbor MI, Michael Smietana - Orion MI, Jinjin Ma - Ann Arbor MI,
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61F 2/28
US Classification:
424423
Abstract:
A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.