Valerie B. Randolph - Lincoln Park NJ Joan C. Crowley - Englewood NJ
Assignee:
American Cyanamid Company - Wayne NJ
International Classification:
A61K 39155 C12N 708
US Classification:
4242111
Abstract:
This invention provides cold adapted mutant RSV, specifically, mutant RSV of subgroup A and B. Nucleic acid molecules encoding the mutant RSV of this invention, and immunogenic polypeptides of these mutant RSV also are provided by this invention. Pharmaceutical compositions containing any of the above compositions are provided herein. These are especially useful as vaccines. Further provided by this invention are methods of vaccinating a subject against RSV infection using the pharmaceutical compositions described herein.
Warner Baker, Alice Dodge, Lucie Nichols, Marie Abare, Robert Roberge, Edmund Blood, Bruce Mcleod, Betty O'neal, Jacqueline Brew, Clyde Gould, Evelyn Leary