Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer's disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequalae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and the promotion of wakefulness.
Name / Title
Company / Classification
Phones & Addresses
Joan Fletcher Director, President
LES ANGES ANTIQUES, INC
895 10 St S STE 302E, Naples, FL 34102
Joan A. Fletcher Treasurer
MINT GREEN USA INC
Joan B Fletcher Manager
2525 FAIRMOUNT, L.P
895 10 St S, Naples, FL 34102 285 Little Hbr Ln, Naples, FL 34102
2007 to 2000 Assist clientAllegro school Springfield, NJ 2007 to 2010 Assistant SupervisorCommunity Access Unlimited Elizabeth, NJ 2006 to 2007 Program CoordinatorGirls and Boys Town of New Jersey Newark, NJ 2006 to 2006 Youth Care WorkerPlus Group Home East Meadow, NY 2002 to 2005 Lead Resident AdvisorAHRC Levittown, NY 2002 to 2003 Activity Coach
Education:
Brown Institute Iselin, NJ Apr 2010 to May 2011 Certificate in Medical AssistantNassau Community College Garden City, NY 1998 to 2002 Associates in Management
Oakton, VAThe founder of Winning Ways, Inc., Joan Fletcher has 20 years of in-depth experience in performance improvement. She opened her own company in 1987, so her... The founder of Winning Ways, Inc., Joan Fletcher has 20 years of in-depth experience in performance improvement. She opened her own company in 1987, so her leadership, sales and speaking experience comes first-hand as well as from working with clients in a variety of industries.
She has conducted...