Joan Sawyer Steffan from 545 Windsor Pl, Laguna Beach, CA 92651, age 71, Phone: (949)3762035

Methods And Reagents For Reducing Polyglutamine Toxicity
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US Patent:

20040235733, Nov 25, 2004
Filed:

Feb 27, 2004
Appl. No.:

10/789518
Inventors:

Joan Steffan - Laguna Beach CA, US
Leslie Thompson - Irvine CA, US
James Marsh - Newport Beach CA, US
International Classification:

A61K038/17
US Classification:

514/012000
Abstract:

Methods for treating neurological diseases and disorders using drugs that are able to block SUMOylation, enhance deSUMOylation, enhance ubiquitination, or inhibit deubiquitination, are provided.

Methods And Reagents For Treating Neurodegenerative Diseases And Motor Deficit Disorders
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US Patent:

20050227915, Oct 13, 2005
Filed:

Jan 29, 2004
Appl. No.:

10/768292
Inventors:

Joan Steffan - Laguna Beach CA, US
Leslie Thompson - Irvine CA, US
J. Marsh - Newport Beach CA, US
Laszlo Bodai - Irvine CA, US
Judit Pallos - Irvine CA, US
Emma Hockly - London, GB
Gillian Bates - London, GB
International Classification:

A61K038/12
A61K031/47
A61K031/44
A61K031/40
A61K031/445
A61K031/19
US Classification:

514009000, 514340000, 514575000, 514557000, 514357000, 514408000, 514602000, 514476000, 514595000, 514616000, 514317000
Abstract:

The invention relates to a novel method for treating a variety of diseases and disorders, including polyglutamine expansion diseases such as Huntington's disease, neurological degeneration, psychiatric disorders, and protein aggregation disorders and diseases, comprising administering to patients in need thereof a therapeutically effective amount of one or more deacetylase inhibitors. The invention is also directed to a transgenic fly useful as a model of polyglutamine expansion diseases, which may be used to test potential therapeutic agents.

Method For Treating Neurodegenerative, Psychiatric, And Other Disorders With Deacetylase Inhibitors
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US Patent:

20040142859, Jul 22, 2004
Filed:

Oct 30, 2003
Appl. No.:

10/476627
Inventors:

Joan Steffan - Laguna Beach CA, US
Leslie Thompson - Irvine CA, US
J. Marsh - Newport Beach CA, US
Laszlo Bodai - Irvine CA, US
Judit Pallos - Irvine CA, US
International Classification:

A61K038/12
A61K031/19
US Classification:

514/009000, 514/575000, 514/557000, 514/568000
Abstract:

The invention relates to a novel method for treating a variety of diseases and disorders, including polyglutamine expansion diseases such as Huntington's disease, neurological degeneration, psychiatric disorders, and protein aggregation disorders and diseases, comprising administering to patients in need thereof of a therapeutically effective amount of one or more deacetylase inhibitors. The invention is also directed to a transgenic fly useful as a model of polyglutamine expansion diseases, which may be used to test potential therapeutic agents.