Joan M Valentine

US Patent:

52003345, Apr 6, 1993

Filed:

Aug 13, 1991

Appl. No.:

7/744524

Inventors:

Bruce S. Dunn - Los Angeles CA
Joan S. Valentine - Encino CA
Jeffrey I. Zink - Sherman Oaks CA
Lisa Ellerby - Los Angeles CA
Fumito Nishida - Los Angeles CA
Clinton Nishida - Los Angeles CA
Stacey A. Yamanaka - Los Angeles CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 1104
C12N 1114
C12N 1108
C03C 300

US Classification:

435182

Abstract:

An active biological material encapsulated in a glass is formed using a sol-gel process. A metal alkoxide is mixed with water and exposed to ultrasonic energy at a pH. ltoreq. 2 to form a single phase solution which is then buffered to a pH between about 5 and 7. The buffered solution is then mixed with the active biological material and the resultant gel is aged and dried. The dried product is a transparent porous glass with substantially all of the added active biological material encapsulated therein, the biological material retaining a high level of activity.