Joanne Mably Chan

US Patent:

20090280130, Nov 12, 2009

Filed:

Jun 13, 2007

Appl. No.:

12/304495

Inventors:

Joanne Chan - Medford MA, US

Assignee:

CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA

International Classification:

A61K 39/395
A61K 31/545

US Classification:

4241451, 514192

Abstract:

p-00010000Bacillus anthracis

US Patent:

6475778, Nov 5, 2002

Filed:

Feb 13, 1998

Appl. No.:

09/023905

Inventors:

Thomas M. Roberts - Cambridge MA
Frederick J. King - Brookline MA
David F. Harris - Gales Ferry CT
Erding Hu - King of Prussia PA
Bruce Spiegelman - Waban MA
Joanne Chan - Brookline MA

Assignee:

Dana-Farber Cancer Institute - Boston MA

International Classification:

C12N 1500

US Classification:

4353201, 435 691, 435325, 435455, 536 231, 536 235

Abstract:

The present invention relates to novel SH3 domain binding protein, referred to herein a DEF polypeptides. The DEF polypeptides comprise several motifs including a src SH3 consensus binding sequence, four ankyrin repeats, one zinc finger domain and six copies of a proline-rich tandem repeat. DEF polypeptides may function as mediators of SH3 domain-dependent signal transduction pathways and, thus may mediate multiple signaling events such as cellular gene expression, cytoskeletal architecture, protein trafficking and endocytosis, cell adhesion, migration, proliferation and differentiation. Described herein are isolated and antisense nucleic acids molecules, recombinant expression vectors, host cells and non-human transgenic animals containing an insertion or a disruption of the DEF gene. Diagnostic, screening and therapeutic methods utilizing the compositions of the invention are also provided.