Joel M Morris

US Patent:

6541481, Apr 1, 2003

Filed:

Apr 12, 2001

Appl. No.:

09/834259

Inventors:

John Charles Kath - Waterford CT
Norma Jacqueline Tom - Waterford CT
Zhengyu Liu - Waterford CT
Eric David Cox - Mystic CT
Joel Morris - East Lyme CT
Samit Kumar Bhattacharya - Groton CT

Assignee:

Pfizer Inc - New York NY

International Classification:

A61K 31505

US Classification:

5142601, 514265, 544280, 544278

Abstract:

The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R , R and R are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.

US Patent:

6890924, May 10, 2005

Filed:

Jun 18, 2001

Appl. No.:

09/883752

Inventors:

John Charles Kath - Waterford CT, US
Joel Morris - East Lyme CT, US
Samit Kumar Bhattacharya - Groton CT, US

Assignee:

Pfizer Inc - New York NY

International Classification:

C07D401/12
C07D403/12
C07D413/12
C07D417/12
A61K031/517

US Classification:

5142345, 5142662, 51426623, 51426621, 544116, 544238, 544283, 544284

Abstract:

The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R, R, R, R, R, m and p are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.

US Patent:

6927220, Aug 9, 2005

Filed:

Apr 12, 2002

Appl. No.:

10/121831

Inventors:

Joel Morris - East Lyme CT, US
Samit K. Bhattacharya - Groton CT, US
John C. Kath - Waterford CT, US

Assignee:

Pfizer Inc - New York NY

International Classification:

C07D471/04
A61K031/519
A61P035/00

US Classification:

51426411, 544279

Abstract:

The invention relates to 6- or 7-bicyclic-substituted 4-amino-subsituted pyridopyrimidines and to pharmaceutically acceptable salts, prodrugs and hydrates thereof. The invention also relates to pharmaceutical compositions containing the compounds and to methods of treating hyperproliferative disorders abnormal cell growth in a mammal by administering the compounds.

US Patent:

7276602, Oct 2, 2007

Filed:

Jul 24, 2003

Appl. No.:

10/626406

Inventors:

Blaise Lippa - Mystic CT, US
Tricia Ann Kwan - Groton CT, US
Joel Morris - East Lyme CT, US
Susan D. LaGreca - Old Lyme CT, US
Matthew David Wessel - Ledyard CT, US

Assignee:

Pfizer Inc - New York NY

International Classification:

C07D 412/02
C07D 417/12

US Classification:

544238, 544405, 5462711, 548213

Abstract:

The invention relates to compounds of the formula 1.

US Patent:

7332493, Feb 19, 2008

Filed:

Mar 14, 2005

Appl. No.:

11/079648

Inventors:

John Charles Kath - Waterford CT, US
Joel Morris - East Lyme CT, US
Samit Kumar Bhattacharya - Groton CT, US

Assignee:

OSI Pharmaceuticals - New York NY

International Classification:

A61K 31/517
C07D 239/84
C07D 401/12
C07D 403/12
C07D 417/12
A61K 31/538
C07D 413/12

US Classification:

51425202, 5142345, 5142662, 51426621, 51426623, 544116, 544238, 544283, 544284

Abstract:

The invention relates to compounds of the formula 1.

US Patent:

7585869, Sep 8, 2009

Filed:

May 20, 2004

Appl. No.:

10/849707

Inventors:

Samit Kumar Bhattacharya - Groton CT, US
Jinshan Chen - Clinton CT, US
Richard Damian Connell - East Lyme CT, US
John Charles Kath - Waterford CT, US
Goss S. Kauffman - Ledyard CT, US
Blaise S. Lippa - Mystic CT, US
Joel Morris - East Lyme CT, US

Assignee:

Pfizer, Inc. - New York NY

International Classification:

A61K 31/517
C07D 239/94

US Classification:

51426622, 544293

Abstract:

The invention relates to compounds of formula 1.

US Patent:

8144757, Mar 27, 2012

Filed:

Jul 23, 2008

Appl. No.:

12/178355

Inventors:

Joel M. Morris - Columbia MD, US
Ronald Hozloehner - Munich, DE
Amitkumar Mahadevan - Baltimore MD, US
Curtis R. Menyuk - Silver Spring MD, US
John W. Zweck - Columbia MD, US

Assignee:

University of Maryland, Baltimore County - Baltimore MD

International Classification:

H04B 3/46

US Classification:

375227

Abstract:

A dual adaptive importance-sampling system and method is provided that can estimate the probability of events by combining dual complementary importance-sampling simulations. The present invention exploits the ability to determine an optimal biased pdf using an iterative procedure that requires relatively little a priori knowledge of how to bias. Hence, the present invention is particularly suited for evaluating the BERs and/or WERs of coded communication and storage systems, and is generally applicable to arbitrarily chosen codes. When applied to coded communication and storage systems, the present invention provides a versatile technique for the fast and accurate estimation of BERs and WERs of FEC codes down to values of 10or lower.

US Patent:

20030186995, Oct 2, 2003

Filed:

Jan 21, 2003

Appl. No.:

10/349475

Inventors:

John Kath - Waterford CT, US
Tom Jacqueline - Waterford CT, US
Liu Zhengyu - Waterford CT, US
Eric Cox - Mystic CT, US
Joel Morris - East Lyme CT, US
Samit Bhattacharya - Groton CT, US

Assignee:

Pfizer Inc.

International Classification:

A61K031/519
A61K031/4745
A61K031/4743
A61K031/4741
C07D498/02
C07D491/02
C07D471/02

US Classification:

514/260100, 514/262100, 514/264100, 514/266400, 544/278000, 544/279000, 544/284000, 544/293000, 544/256000, 546/113000, 546/114000, 546/115000, 546/122000, 514/300000, 514/301000, 514/302000

Abstract:

The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R, Rand Rare as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.