John P Byrnes

US Patent:

20100204286, Aug 12, 2010

Filed:

Feb 11, 2010

Appl. No.:

12/704286

Inventors:

Stephen R. Donahue - Lexington MA, US
John J. Byrnes - Ashland MA, US

International Classification:

A61K 31/426
A61K 31/4172
A61K 31/415
A61P 35/00
A61P 1/00

US Classification:

514365, 514400, 514406

Abstract:

A method for moderating a gastrointestinal adverse effect induced by at least one cytotoxic agent, for example ionizing radiation and/or at least one chemotherapeutic agent, in a subject comprises administering to the subject a therapeutically effective amount of an ACE2 inhibitor or a compound selected from (S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl]-ethylaminol-4-methylpentanoic acid (ORE1001), pharmaceutically acceptable salts thereof and prodrugs thereof. A method for treating a cancerous condition in a subject comprises administering to the subject (a) at least one cytotoxic anticancer agent, for example ionizing radiation and/or at least one chemotherapeutic agent; and (b) an ACE2 inhibitor or a compound selected from ORE1001, pharmaceutically acceptable salts thereof and prodrugs thereof in an amount effective to moderate a gastrointestinal adverse effect induced by the anticancer agent.