John William Carson

US Patent:

6369228, Apr 9, 2002

Filed:

Feb 5, 2001

Appl. No.:

09/777087

Inventors:

John R. Carson - Norristown PA
Philip M. Pitis - North Wales PA
Kathryn E. Rogers - Audubon PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07D21700

US Classification:

546146, 546208

Abstract:

Aroyl aminoacyl pyrroles are pharmaceutically useful in treating neuropathic pain, which includes utility for the treatment of neuropathic pain.

US Patent:

6436959, Aug 20, 2002

Filed:

Dec 23, 1998

Appl. No.:

09/220189

Inventors:

John R. Carson - Norristown PA
Richard J. Carmosin - late of Quakertown PA
Louis J. Fitzpatrick - Souderton PA
Allen B. Reitz - Lansdale PA
Michele C. Jetter - Norristown PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 314468

US Classification:

514326, 514329, 546224, 546208

Abstract:

4-[aryl(piperidin-4-yl)]aminobenzamides are delta-opioid receptor agonists/antagonists. As delta-opioid receptor agonists, such compounds are useful as analgesics. Depending on their agonist/antagonist effect, such compounds may also be useful immunosuppressants, antiinflammatory agents, agents for the treatment of mental illness, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents, and agents for the treatment of respiratory diseases.

US Patent:

6465486, Oct 15, 2002

Filed:

Mar 10, 2000

Appl. No.:

09/524451

Inventors:

Ellen W. Baxter - Glenside PA
Robert E. Boyd - Horsham PA
John R. Carson - Norristown PA
Michele C. Jetter - Norristown PA
Allen B. Reitz - Lansdale PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3147

US Classification:

514311, 514314, 546167, 546165, 546178, 5462727, 5462751, 546341

Abstract:

Certain imidazo pyridines/quinolines of the formula: where n is 0, 1, 2; X is independently selected from the group consisting of C alkyl, bromine, chlorine, iodide, trifluoromethyl, C alkoxy, âSO NH , nitro, and two adjacent X may be fused to form the moiety: âwhereby a saturated, partially unsaturated or aromatic six-membered fused ring is formed; Y is independently selected from the group consisting of hydrogen, hydroxy, C alkyl, C alkoxy, trifluoromethyl and phenyl; and Z is independently selected from the group consisting of hydroxy, C alkyl, bromine, chlorine, iodide, trifluoromethyl, C alkoxy, âSO NH and nitro; are -adrenoceptor modulators which are useful in the treatment of hypertension, glaucoma, sexual dysfunction, depression, attention deficit hyperactivity disorder, Parkinsonism, the need for anesthesia, cardiac arrythmia or the need for analgesia.

US Patent:

6492387, Dec 10, 2002

Filed:

Dec 11, 2001

Appl. No.:

10/015038

Inventors:

John R. Carson - Norristown PA
Philip M. Pitis - North Wales PA

Assignee:

Ortho-McNeil Pharamaceutical, Inc. - Raritan NJ

International Classification:

C07D 40102

US Classification:

514307, 514416, 546146, 548465

Abstract:

This invention is directed to isoindolyl and isoquinolinyl aroyl pyrrole compounds pharmaceutically useful as agents or modulators for the treatment of central nervous system disorders and methods for the treatment of central nervous system disorders.

US Patent:

6552036, Apr 22, 2003

Filed:

Feb 22, 2001

Appl. No.:

09/791246

Inventors:

Robert E. Boyd - Horsham PA
John R. Carson - Norristown PA
Steven J. Coats - Quakertown PA
Lou Anne Neilson - Sellersville PA
Philip M Pitis - North Wales PA
Wu-Nan Wu - Landsdale PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07D45102

US Classification:

514299, 546112

Abstract:

This invention is directed to 3-(diarylmethylene)-8-azabicyclo[3. 2. 1]octane derivatives useful as -opioid or -opioid receptor modulators. Depending on their agonist or antagonist effect, the compounds are useful analgesics, immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psychiatric conditions, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents and agents for the treatment of respiratory diseases.

US Patent:

6573267, Jun 3, 2003

Filed:

Jun 29, 2001

Appl. No.:

09/896084

Inventors:

John R. Carson - Norristown PA
Philip M. Pitis - North Wales PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3140

US Classification:

51425401, 5142278, 5142355, 514326, 514343, 514397, 514422, 514423, 544 582, 544 585, 544141, 544372, 546208, 5462791, 5483147, 548518, 548527, 548539

Abstract:

This invention is directed to aroyl aminoacyl pyrroles pharmaceutically useful as agents and modulators for the treatment of central nervous system disorders and a method for the treatment of central nervous system disorders including, but not limited to, use of the compounds of the present invention as anticonvulsant agents and modulators, antiepileptic agents and modulators, neuroprotective agents and modulators, muscle relaxant agents and modulators and as agents and modulators for the treatment of neuropathic pain.

US Patent:

6897319, May 24, 2005

Filed:

Dec 10, 2002

Appl. No.:

10/315585

Inventors:

John R. Carson - Norristown PA, US
Ellen E. Codd - Blue Bell PA, US
Philip M. Pitis - North Wales PA, US

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K031/4439
A61K031/4178
C07D401/06
C07D401/14
C07D403/06

US Classification:

5462791, 546146, 546168, 5462681, 546256, 5483147, 5483141, 548517, 548518, 548527, 548539, 514343, 514397, 514422, 514314, 514307

Abstract:

This invention is directed to aroyl pyrrole heteroaryl methanone and methanol compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a central nervous system disorder.

US Patent:

6958349, Oct 25, 2005

Filed:

Mar 31, 2003

Appl. No.:

10/403186

Inventors:

John R. Carson - Norristown PA, US
Michele C. Jetter - Norristown PA, US
Jung S. Lee - Ambler PA, US
Mark A. Youngman - Warminster PA, US

Assignee:

Ortho-McNeil Pharmaceuticals, Inc. - Raritan NJ

International Classification:

A61K031/47
C07D215/12
C07D215/16

US Classification:

514314, 546174, 546175, 546177

Abstract:

This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alkylamide derivatives as bradykinin receptor agonists useful for the treatment of bradykinin modulated disorders such as hypertension and the like.