John D Clifford

US Patent:

6043272, Mar 28, 2000

Filed:

Nov 20, 1997

Appl. No.:

8/975391

Inventors:

Carlo Brugnara - Newton Highlands MA
Jose Halperin - Brookline MA
Rudolf Fluckiger - Brookline MA
Emile Bellot - Beverly MA
Richard John Lombardy - Littleton MA
John J. Clifford - Arlington MA
Reem M. Haidar - Woburn MA
Eugene W. Kelleher - Somerville MA
Adel M. Moussa - Burlington MA
Yesh P. Sachdeva - Concord MA
Minghua Sun - Libertyville IL
Heather N. Taft - Littleton MA

Assignee:

Ion Pharmaceuticals, Inc. - New York NY
President and Fellows of Harvard College - Cambridge MA
Children's Medical Center Corporation - Boston MA

International Classification:

A61K 31335
C07C25500
C07C 6976
C07C 6952

US Classification:

514467

Abstract:

The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

US Patent:

6460844, Oct 8, 2002

Filed:

Oct 31, 2000

Appl. No.:

09/702497

Inventors:

John W. Clifford - Ashland MA
Steven P. Lewalski - Melrose MA
Matthew D. Bouche - Tyngsboro MA
Bruce J. Taylor - Manchester NH

Assignee:

Roll Systems, Inc. - Burlington MA

International Classification:

B65H 3902

US Classification:

271 913, 271 912, 271251, 271303, 271197, 270 5209, 270 5801, 83934

Abstract:

An apparatus for selectively streaming and merging side-by-side sheets is provided. In general, sheets enter in a side-by-side orientation onto an input feed surface and are directed selectively upwardly or downwardly onto overlying upper and lower feed surfaces by a diverter assembly having two diverter sides. The diverter sides can be independently moved to direct sheets upwardly or downwardly. The upper feed surface and lower feed surface have opposing edge guides. The upper feed surface and lower feed surface can be moved with respect to each other so that the edge guides are placed one sheet width apart or more than two sheet widths apart. By orienting the two diverter halves, and setting the desired distance between the upper and lower edge guides, sheets can pass along each of the upper and lower surfaces in a side-by-side streamed or over-lapping merge orientation. Sheets pass out of each of the upper and lower feed surfaces onto a common output surface through an output ramp at which time they are either side-by-side streamed or merged. Each edge guide can include an offset actuator that moves at selected times to provide an offset to selected sheets as they enter the output feed ramp.

US Patent:

6534497, Mar 18, 2003

Filed:

Sep 22, 2000

Appl. No.:

09/554848

Inventors:

Carlo Brugnara - Newton Highlands MA
Jose Halperin - Brookline MA
Rudolf Fluckiger - Brookline MA
Richard John Lombardy - Littleton MA
John J. Clifford - Bedford MA
Reem M. Haidar - Woburn MA
Eugene W. Kelleher - Somerville MA
Adel M. Moussa - Burlington MA
Yesh P. Sachdeva - Concord MA
Minghua Sun - Cambridge MA
Heather N. Taft - Littleton MA
Michael H. Zeldin - Cambridge MA

Assignee:

Nuchem Pharmaceuticals, Inc. - Markham
Childrens Medical Center Corporation - Boston MA
Presidents and Fellows of Harvard College - Cambridge MA

International Classification:

C07D22320

US Classification:

514217, 540587

Abstract:

The present invention provides substituted 11-phenyl-dibenzazepine compounds that are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

US Patent:

6800658, Oct 5, 2004

Filed:

Jan 10, 2002

Appl. No.:

10/043640

Inventors:

Carlo Brugnara - Newton Highlands MA
Jose Halperin - Brookline MA
Rudolf Fluckiger - Brookline MA
Richard John Lombardy - Littleton MA
John J. Clifford - Arlington MA
Reem M. Haidar - Woburn MA
Eugene W. Kelleher - Somerville MA
Adel M. Moussa - Burlington MA
Yesh P. Sachdeva - Concord MA
Minghua Sun - Cambridge MA
Heather N. Taft - Littleton MA

Assignee:

Childrens Medical Center Corporation - Cambridge MA
President Fellows of Harvard College - Cambridge MA
Nuchem Pharmaceuticals, Inc.

International Classification:

C07C 2200

US Classification:

514467, 514475, 514544, 514546, 514640, 514617, 514717, 549430, 549453, 549550, 558388, 560 56, 560 57, 560221, 564180, 564265

Abstract:

The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

US Patent:

6817566, Nov 16, 2004

Filed:

Oct 30, 2002

Appl. No.:

10/283701

Inventors:

John W. Clifford - Ashland MA
Andrew P. Butler - Marion MA
Peter E. Bianchetto - Foxboro MA
Pierre Gachet - Mouxy, FR
Robert Mavilia - Braintree MA

Assignee:

Butler Automatic, Inc. - Middleborough MA

International Classification:

B65H 1914

US Classification:

242552, 2425541, 2425542, 2425594, 2425982, 2425993, 156564

Abstract:

A web handling apparatus includes a base, a housing, a splicing head mounted in the housing, and first and second non-rotatable swing out roll shafts, each shaft having opposite first and second ends. The roll shafts are normally positioned in the housing substantially parallel to the splicing head so that web can travel through the splicing head to on from web rolls on the roll shafts. A web accumulator mounted to the housing conducts web to or from the splicing head and the housing is movably mounted to the base so that the housing can move relative to the base in either direction parallel to the roll shafts. An actuator connected between the housing and the base moves the housing relative to the base in response to signals from a web position sensor so as to minimize the side lay of web extending to or from the apparatus. The splicing head employs special mirror image upper and lower splicing sections which facilitate preparation of the leading end of the ready web while the other web is running and the two splicing sections cooperate to make a consistent high quality butt or lap splices between the two webs.

US Patent:

6992079, Jan 31, 2006

Filed:

Dec 7, 2001

Appl. No.:

10/013308

Inventors:

Carlo Brugnara - Newton Highlands MA, US
Jose Halperin - Brookline MA, US
Rudolf Fluckiger - Brookline MA, US
Richard John Lombardy - Littleton MA, US
John J. Clifford - Arlington MA, US
Reem M. Haidar - Woburn MA, US
Eugene W. Kelleher - Medford MA, US
Adel M. Moussa - Burlington MA, US
Yesh P. Sachdeva - Concord MA, US
Minghua Sun - Libertyville IL, US
Heather N. Taft - Littleton MA, US
Michael H. Zeldin - Cambridge MA, US

Assignee:

President Fellows of Harvard College - Cambridge MA
Children's Medical Center Corporation - Boston MA
NuChem Pharmaceuticals Inc. - Toronto

International Classification:

A61K 31/55
C07D 233/18

US Classification:

514217, 540587

Abstract:

The present invention provides substituted 11-phenyl-dibenzazepine compounds which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

US Patent:

7342038, Mar 11, 2008

Filed:

Jun 1, 2004

Appl. No.:

10/858975

Inventors:

Carlo Brugnara - Newton Highlands MA, US
Jose Halperin - Brookline MA, US
Rudolf Fluckiger - Brookline MA, US
Richard John Lombardy - Littleton MA, US
John J. Clifford - Bedford MA, US
Reem M. Haidar - Woburn MA, US
Eugene W. Kelleher - Somerville MA, US
Adel M. Moussa - Burlington MA, US
Yesh P. Sachdeva - Concord MA, US
Minghua Sun - Cambridge MA, US
Heather N. Taft - Littleton MA, US

Assignee:

President and Fellow of Harvard College - Cambridge MA
Children's Medical Center Corporation - Boston MA
NuChem Pharmaceuticals Inc. - Toronto

International Classification:

C07D 209/10
C07D 209/12
A61K 31/404

US Classification:

514415, 548469, 548483, 548490

Abstract:

The present invention provides substituted 3,3-diphenyl indole compounds, as well as analogues thereof, which are specific potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

US Patent:

7531573, May 12, 2009

Filed:

Jun 3, 2003

Appl. No.:

10/454372

Inventors:

Carlo Brugnara - Newton Highlands MA, US
Jose Halperin - Brookline MA, US
Mark Froimowitz - Newton Centre MA, US
Richard John Lombardy - Littleton MA, US
John J. Clifford - Bedford MA, US
Reem M. Haidar - Woburn MA, US
Eugene W. Kelleher - Bedford MA, US
Falguni M. Kher - Billerica MA, US
Adel M. Moussa - Burlington MA, US
Yesh P. Sachdeva - Concord MA, US
Minghua Sun - Libertyville IL, US
Heather N. Taft - Littleton MA, US

Assignee:

Children's Medical Center Corporation - Boston MA

International Classification:

A61K 31/275

US Classification:

514519, 514520, 514521

Abstract:

The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.