John D Czaban

US Patent:

44106319, Oct 18, 1983

Filed:

Jun 15, 1981

Appl. No.:

6/271321

Inventors:

John D. Czaban - Bradford MA
Alan D. Cormier - Newburyport MA

Assignee:

Instrumentation Laboratory Inc. - Lexington MA

International Classification:

G01N 2726
C09K 300

US Classification:

436 8

Abstract:

A reference liquid system for use with a chemical analyzer that has a plurality of ion selective electrodes comprises a plurality of reference liquids, each of which has a first salt component such that ions of a first element to be measured are present in a predetermined concentration, a second salt component such that ions of a second element to be measured are present in a predetermined concentration, and an error compensation salt component present in a concentration effective to adjust (a) the activity coefficient factor and/or (b) the junction potential factor to reduce the error involved in use of the compensated reference liquid to less than fifty percent of the error involved in use of a corresponding uncompensated reference liquid.

US Patent:

53669045, Nov 22, 1994

Filed:

Apr 21, 1992

Appl. No.:

7/871491

Inventors:

Humayun Qureshi - Wayland MA
Stanley M. Liffmann - Andover MA
John D. Czaban - Beverly MA

Assignee:

DRD Diluter Corporation - Danvers MA

International Classification:

G01N 100
G01N 3348

US Classification:

436180

Abstract:

A measured amount of a first fluid is metered into a measured amount of a second fluid by a method where a fluid is confined within a first chamber and a plunger of predetermined volume is mechanically moved into the chamber to displace a first measured amount of fluid after which a second plunger is mechanically moved into a defined volume of the chamber to displace a second volume of fluid therefrom different from the first volume whereupon the first and second volumes can be mixed in predetermined proportions.

US Patent:

45310882, Jul 23, 1985

Filed:

Aug 6, 1982

Appl. No.:

6/405870

Inventors:

John D. Czaban - Bradford MA
Alan D. Cormier - Newburyport MA
Kenneth D. Legg - Wellesley MA

Assignee:

Allied Corporation - Morristown NJ

International Classification:

G01N 2700

US Classification:

324 711

Abstract:

Rapid and accurate whole blood analysis measurements are made with analysis systems of the potentiometric type that employ restricted diffusion type liquid junctions where the whole blood sample is flowed past sensing electrode and liquid junction at a velocity of at least one centimeter per second during a data acquisition interval that is at least twenty-five milliseconds in duration.

US Patent:

43993621, Aug 16, 1983

Filed:

Feb 27, 1981

Appl. No.:

6/239025

Inventors:

Alan D. Cormier - Newburyport MA
John D. Czaban - Bradford MA
Thomas J. Schillinger - Stoughton MA
Kenneth D. Legg - Wellesley MA
Thomas F. Kelley - Canton MA

Assignee:

Instrumentation Laboratory Inc. - Lexington MA

International Classification:

G01N 2101

US Classification:

250430

Abstract:

A clinical analyzer system flows a small volume (less than 200 microliters) of liquid sample to be analyzed from an inlet port past a sensor array to a series of analysis chambers. The sensor array includes two optical sensor units that are spaced a fixed distance apart, and each sensor unit transmits a beam of infrared radiation through the flow tube for sensing by a detector. Each detector output has a low value when blood is in the flow tube, an intermediate value when air is in the flow tube, and a high value when a clear liquid is in the flow tube. Control logic senses changes in the outputs of the detectors and accurately indicates gas-liquid interface transitions. The noninvasive system accurately locates leading and trailing edges of samples of biological fluids to be analyzed, monitors the integrity of those samples, and distinguishes between types of sample liquids processed by the analyzer.

US Patent:

49418084, Jul 17, 1990

Filed:

Jun 29, 1988

Appl. No.:

7/213169

Inventors:

Humayun Qureshi - Wayland MA
Stanley M. Liffmann - Andover MA
John D. Czaban - Beverly MA

International Classification:

F04B 1300

US Classification:

417415

Abstract:

A multi-mode, differential fluid displacement pump provides for at least two different measured doses. The pump has a chamber in which are mounted a first diameter piston and a second diameter piston defining first and second volumes for reciprocation in the chamber. Means are provided for reciprocating the pistons as desired to obtain predetermined volume changes corresponding to movement of either or both of the first and second pistons. A system of operation and a mixing chamber useful in connection with dosages from the pump are interconnected with the pump.

US Patent:

50377370, Aug 6, 1991

Filed:

Jun 29, 1988

Appl. No.:

7/213258

Inventors:

Stanley M. Liffmann - Andover MA
Humayun Qureshi - Wayland MA
John D. Czaban - Beverly MA

Assignee:

Apec, Inc. - Danvers MA

International Classification:

C12Q 154
C12Q 160
C12Q 106

US Classification:

435 11

Abstract:

A method and apparatus for analyzing a sample to determine an analyte content has a sensor for sensing the analyte positioned between a first and second transducer. The analyte or derivatives thereof are reciprocated between the first and second transducer to reciprocate at the sensor and allow instantaneous sensing of an indication of the analyte's presence at a point between the first and second transducer. Rapid analysis can be carried out in many different systems including for example where the transducers are enzyme reactors and the analytes are body metabolites.

US Patent:

42832624, Aug 11, 1981

Filed:

Jul 1, 1980

Appl. No.:

6/165051

Inventors:

Alan D. Cormier - Newburyport MA
Milo E. Webster - Braintree MA
John D. Czaban - Bradford MA
Neil D. Silverman - Framingham MA
Lynn W. Noble - Acton MA

Assignee:

Instrumentation Laboratory Inc. - Lexington, MA

International Classification:

G01N 2728
G01N 3508

US Classification:

204195M

Abstract:

A system for analyzing a biological fluid specimen or the like includes an analysis chamber and an electrochemical electrode measuring system connected in sensing relation to the analysis chamber. A flow network connects a sample inlet port and an auxiliary fluid reservoir to the analysis chamber. The flow network includes a sample line connected between the sample inlet port and the analysis chamber and an auxiliary manifold connected to the auxiliary fluid reservoir. A positive displacement pump is connected in the sample line between the analysis chamber and a waste outlet port. A valved T-connection is provided between the sample line and the manifold; an inlet isolation valve is in the sample flow path between the sample inlet and the valved T-connection; an analysis chamber isolation valve is in the sample flow path between the valved T-connection and the analysis chamber; and both the sample line and the manifold have a vent valve, the sample line vent valve being connected between the inlet and chamber isolation valves and the manifold vent valve being connected upstream of the auxiliary fluid reservoir. Coordinated operation of the several valves permits the pump to selectively flow fluid from the auxiliary reservoir or a sample through the analysis chamber, together with imposition of nonlaminar flow conditions by concurrent operation of the vent valves to provide effective cleaning of flow surfaces and analysis chambers.