John L Daniel

US Patent:

48809179, Nov 14, 1989

Filed:

Jul 1, 1988

Appl. No.:

7/214229

Inventors:

Peter B. Anzeveno - Zionsville IN
John K. Daniel - Indianapolis IN
Laura J. Creemer - Indianapolis IN
Paul S. Liu - Cincinnati OH

Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH

International Classification:

C07H 1500
C07H 1700
C07H 1702

US Classification:

536 174

Abstract:

A procedure for the mild conversion of a carbonitrile to the corresponding carboxylic acid by first using trifluoroacetic acid in the presence of a catalytic amount of mercuric ion followed by oxidative hydrolysis with dinitrogen tetroxide is described herein. The use of this procedure in the preparation of 1,3,4,5-tetra-O-benzoyl-2,6-dideoxy-2,6-imino-D-glycero-L-gulo-heptitol hydrochloride is also described here.

US Patent:

43282440, May 4, 1982

Filed:

May 21, 1980

Appl. No.:

6/152076

Inventors:

John K. Daniel - Indianapolis IN
Donald P. Matthews - Indianapolis IN
Norton P. Peet - Indianapolis IN

Assignee:

The Dow Chemical Company - Midland MI

International Classification:

A61K 31275
A61K 31185
C07C14358
C07C12150

US Classification:

424304

Abstract:

Novel (((substituted-phenyl)methyl)amino)benzenesulfonic acids having antiviral activity are disclosed. Compounds within the scope of the invention have the formula ##STR1## wherein R. sub. 1 represents lower alkyl, lower alkoxy, nitro, amino, cyano, trifluoromethyl, acetyl, methylthio, methylsulfinyl, methylsulfonyl, benzoyl, substituted benzoyl, aminosulfonyl or halogen; and R. sub. 2 and R. sub. 3 are the same or different and are selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, amino, cyano, trifluoromethyl, acetyl, methylthio, methylsulfinyl, methylsulfonyl, benzoyl, substituted benzoyl, aminosulfonyl or halogen. The invention also includes the pharmaceutically-acceptable salts of the novel (((substituted-phenyl)methyl)amino)benzenesulfonic acids. Methods of using the compounds as antiviral agents are also disclosed, as well as compositions which comprise a carrier in combination with a suitable antiviral active compound.

US Patent:

50175637, May 21, 1991

Filed:

May 1, 1990

Appl. No.:

7/519350

Inventors:

Paul S. Liu - Cincinnati OH
Barry L. Rhinehart - Cincinnati OH
John K. Daniel - Indianapolis IN

Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH

International Classification:

C07D47104
A61K 31445

US Classification:

514 27

Abstract:

Castanospermine mono- and di-esters and glycosides active as inhibitors of carbohydrate digestive enzymes and useful in treating diabetes are described herein. The compounds are prepared by the reaction of castanospermine with an appropriate acid halide or anhydride or with an appropriate glycosyl halide or glycosyl acetimidate under conditions which would favor the isolation of the mono- and di-esterified and glycosylated products. Various blocking groups, which can be selectively removed under mild conditions, can also be used to favor the formation of certain isomers.

US Patent:

42774926, Jul 7, 1981

Filed:

May 21, 1980

Appl. No.:

6/152000

Inventors:

John K. Daniel - Indianapolis IN
Norton P. Peet - Indianapolis IN

Assignee:

The Dow Chemical Company - Midland MI

International Classification:

C07C14358
A61K 31185
C07C12100
A61K 31275

US Classification:

424304

Abstract:

Novel 4-bis((phenylmethyl)amino)benzenesulfonic acids and their pharmaceutically-acceptable salts are described. The compounds exhibit antiviral activity. Methods of using the compounds as antiviral agents are disclosed and also pharmaceutically-acceptable compositions.

US Patent:

42541255, Mar 3, 1981

Filed:

Apr 7, 1980

Appl. No.:

6/137662

Inventors:

Shyam Sunder - Indianapolis IN
John K. Daniel - Indianapolis IN
Norton P. Peet - Indianapolis IN

Assignee:

The Dow Chemical Company - Midland MI

International Classification:

A61K 31495
C07D24116

US Classification:

424250

Abstract:

A series of 2-chloro-3-phenoxypyrazines and 2-chloro-6-phenoxypyrazines exhibiting antiviral activity are disclosed. Methods of using the disclosed compounds as antiviral agents are also described as well as pharmaceutically-acceptable compositions.

US Patent:

45887330, May 13, 1986

Filed:

Oct 19, 1984

Appl. No.:

6/663020

Inventors:

Thomas M. Bargar - Zionsville IN
John K. Daniel - Indianapolis IN

Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH

International Classification:

A61K 3144
C07D491052

US Classification:

514302

Abstract:

2-Phenylpyrano[2,3-b]pyridines are described herein. These compounds are active against a variety of viruses. A number of procedures can be used to prepare the compounds of this invention but, at some point, they would all make use of the cyclization of a (phenyl) (pyridyl)propanol or (phenyl) (pyridyl)propenol.