John E Delaney

US Patent:

8075908, Dec 13, 2011

Filed:

Jul 15, 2008

Appl. No.:

12/173480

Inventors:

John P. Delaney - Minneapolis MN, US

Assignee:

Anhese LLC - Minneapolis MN

International Classification:

A61K 9/00
A61K 31/336
A61K 31/205
A61K 31/365
A61K 31/439
A61K 9/14

US Classification:

424423, 514475, 514563, 514473, 514291, 424489

Abstract:

A method for inhibiting formation of adhesions following abdominal surgery which involves application of an anti-static fatty acid ethoxylated amide (Cocamide DEA) in a matrix that is placed in the peritoneal cavity at the conclusion of an abdominal surgery and which releases this anti-adhesive chemical over a predetermined time in a range from about five to seven days. Tests conducted on laboratory rats established that the method reduced the incidences of adhesions from 100 percent (100%) in a test model to near zero percent (0%) in the treated animals. In an alternative embodiment, Andrographalide was delivered through a drug pump with similar results. In still another embodiment, an effective amount of Rapamune was delivered, via a pump, into the abdominal cavity, again with similar results.

US Patent:

20120070473, Mar 22, 2012

Filed:

Nov 22, 2011

Appl. No.:

13/302563

Inventors:

John P. Delaney - Minneapolis MN, US

Assignee:

ANHESE LLC - Minneapolis MN

International Classification:

A61K 9/00
A61K 31/164
A61P 43/00
A61K 31/685
A61K 31/365
B82Y 5/00

US Classification:

424400, 514 78, 514473, 514625, 977906

Abstract:

A method for inhibiting formation of adhesions following abdominal surgery which involves application of an anti-static fatty acid ethoxylated amide (Cocamide DEA) in a matrix that is placed in the peritoneal cavity at the conclusion of an abdominal surgery and which releases this anti-adhesive chemical over a predetermined time in a range up to seven days. Tests conducted on laboratory rats established that the method reduced the incidence of adhesions from 100 percent (100%) in a test model to near zero in the majority of treated animals. In an alternative embodiment, andrographalide was delivered via a pump with similar results. In still another embodiment, an effective amount of 50% phosphatidylchorene and propylene glycol was delivered, via a pump, into the abdominal cavity, again with similar results.

US Patent:

20150010636, Jan 8, 2015

Filed:

Sep 10, 2014

Appl. No.:

14/482187

Inventors:

John P. Delaney - Minneapolis MN, US

Assignee:

ANHESE LLC - Minneapolis MN

International Classification:

A61K 31/436
A61K 31/341
A61M 5/145
A61K 47/10
A61K 9/00
A61K 31/16
A61K 47/24

US Classification:

424489, 514625, 514473, 514291, 604506

Abstract:

A method for inhibiting formation of adhesions following abdominal surgery which involves application of an anti-static fatty acid ethoxylated amide (Cocamide DEA) in a matrix that is placed in the peritoneal cavity at the conclusion of an abdominal surgery and which releases this anti-adhesive chemical over a predetermined time in a range up to seven days. Tests conducted on laboratory rats established that the method reduced the incidence of adhesions from 100 percent (100%) in a test model to near zero in the majority of treated animals. In an alternative embodiment, andrographalide was delivered via a pump with similar results. In still another embodiment, an effective amount of 50% phosphatidylchorene and propylene glycol was delivered, via a pump, into the abdominal cavity, again with similar results.