John B Garvey

US Patent:

20120230966, Sep 13, 2012

Filed:

Sep 24, 2010

Appl. No.:

13/499004

Inventors:

Keith D. Crawford - Westwood MA, US
Pamela Layton - Westwood MA, US
John M. Garvey - Londonderry NH, US

Assignee:

PARCELL LABORATORIES LLC - Westwood MA
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA

International Classification:

A61K 35/14
C12N 5/071
A61P 19/04
A61P 17/00
A61P 19/00

US Classification:

424 9371, 435325

Abstract:

Provided are transplants and methods for augmenting formation and restoration of organ and tissue, for example, bone formation, by administering autologous or allogeneic human embryonic-like adult stem cells (ELA cells). Also provided is a method for augmenting formation of tissues and organs by administering a transplant having ELA stem cells or combination of ELA stem cells.

US Patent:

20150010501, Jan 8, 2015

Filed:

Sep 26, 2014

Appl. No.:

14/497690

Inventors:

- Natick MA, US
Pamela Layton - Westwood MA, US
John Garvey - Londonderry NH, US
Jeffrey A. Gadboys - Gulf Breeze FL, US

International Classification:

A61K 35/24
A61K 35/14
C12N 5/074

US Classification:

424 852, 435325, 424 937, 4352831

Abstract:

The present invention provides compositions, methods and devices for treatment of degenerative disc disease or the repair of a disc in need of repair. The composition or the formulation includes freshly isolated or culture expanded ELA cells, which can be cyropreserved. The composition or a formulation also includes in various embodiments an ELA cell population that has been differentiated into cell types having at least one characteristic of human intervertebral disc cells, such as fibroblast cells, chondrocyte cells or notochordal cells. The composition or the formulation includes in certain embodiments either a population of ELA cells provided in conjunction with one or more biocompatible molecules, therapeutic agents, or agents that induce ELA stem cell differentiation. The ELA cells are obtained from fluid or tissue from live or cadaveric (cadaverous) donors. Treatment of a degenerative disc or a disc in need of repair includes in various embodiments one or more injections or implantations of the composition comprising the ELA cells within or in association with the disc in need of repair.