John A Gilmore

US Patent:

7074810, Jul 11, 2006

Filed:

Oct 3, 2003

Appl. No.:

10/678331

Inventors:

Bryan W. King - Blue Bell PA, US
James Sheppeck - Newtown PA, US
John L. Gilmore - Yardley PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/44
C07D 401/00

US Classification:

514340, 5462724

Abstract:

The present application describes novel hydantoin derivatives of formula (I):.

US Patent:

7211671, May 1, 2007

Filed:

Sep 21, 2004

Appl. No.:

10/946418

Inventors:

James Sheppeck - Newtown PA, US
John L. Gilmore - Yardley PA, US
Xiaohua He - Hockessin DE, US

Assignee:

Bristol Myers Squibb Company - Princeton NJ

International Classification:

C07D 401/12

US Classification:

546152, 5483164, 5483251

Abstract:

The present invention describes novel 1,3-dihydro-imidazol-2-one or 1,3-dihydro-imidazol-2-thione compounds of formula (I):.

US Patent:

7569689, Aug 4, 2009

Filed:

Jan 13, 2005

Appl. No.:

11/034652

Inventors:

Jingwu Duan - Yardley PA, US
Bin Jiang - Norristown PA, US
James Sheppeck - Newtown PA, US
John L. Gilmore - Yardley PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/498
C07D 417/14

US Classification:

544343, 514250

Abstract:

A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I).

US Patent:

7625921, Dec 1, 2009

Filed:

Jan 13, 2005

Appl. No.:

11/034822

Inventors:

Jingwu Duan - Yardley PA, US
James Sheppeck - Newtown PA, US
Bin Jiang - Norristown PA, US
John L. Gilmore - Yardley PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/4748
C07D 401/14
C07D 417/12

US Classification:

514289, 546 74, 546 63, 514286

Abstract:

A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I).

US Patent:

8067447, Nov 29, 2011

Filed:

Oct 31, 2007

Appl. No.:

12/513192

Inventors:

James E. Sheppeck - Newtown PA, US
John L. Gilmore - Yardley PA, US
T. G. Murali Dhar - Newtown PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/433
A61K 31/416
C07D 285/135
C07D 231/56
C07D 231/40

US Classification:

514363, 514406, 548139, 5483625

Abstract:

Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, and/or AP-1, and/or NF-κB activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I), its enantiomers, diastereomers, or a pharmaceutically-acceptable salt, or hydrate, thereof, wherein (Ia) is heterocycle or heteroaryl; J, Ja, E, F, G, Ma, M, Q, Za and Z are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases and obesity and diabetes employing said compounds.

US Patent:

8198311, Jun 12, 2012

Filed:

Oct 31, 2007

Appl. No.:

12/513232

Inventors:

James E. Sheppeck - Newtown PA, US
John L. Gilmore - Yardley PA, US
T. G. Murali Dhar - Newtown PA, US
Jianmin Wang - Blacksburg VA, US
Bingwei Vera Yang - Belle Mead NJ, US
Lidia M. Doweyko - Long Valley NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/416
C07D 231/56

US Classification:

514406, 5483625

Abstract:

Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I), its enantiomers, diastereomers, or a pharmaceutically acceptable salt, or hydrate, thereof, wherein X is (Ia); or X is (Ib); or X is (Ic); (Id) is heterocycle or heteroaryl; E is —N—, —NR—, —O—, —S—, —SO— or —CR—; F is —N—, —NR—, —O—, —S—, —SO— or —CR—; G is N, —NR—, —O—, —S—, —SO— or —CR—, provided that the E-F-G containing heterocyclic ring formed does not contain a S—S or S—O bond, and at least one of E, F and G is a heteroatom; J, J, M, M, Q, R, R, R, R, R, R, R, R, and Rto R, Z, Z, Z, and Zare as defined above.

US Patent:

8399451, Mar 19, 2013

Filed:

Aug 5, 2010

Appl. No.:

12/850892

Inventors:

John L. Gilmore - Yardley PA, US
James E. Sheppeck - Newtown PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/4245
A61K 31/454
A61K 31/4439
A61K 31/506
A61K 31/4545
A61K 31/5377
A61K 31/497
C07D 413/14
C07D 413/04
C07D 417/14

US Classification:

5142102, 514326, 514364, 514342, 514256, 514318, 5142362, 51425403, 544138, 544333, 544369, 546194, 5462711, 546209, 548131, 548950

Abstract:

Disclosed are compounds of Formula (I).

US Patent:

7361654, Apr 22, 2008

Filed:

Jan 12, 2006

Appl. No.:

11/330553

Inventors:

James Sheppeck - Newtown PA, US
T. G. Murali Dhar - Newtown PA, US
Lidia Doweyko - Long Valley NJ, US
John Gilmore - Yardley PA, US
David Weinstein - East Windsor NJ, US
Bingwei V. Yang - Belle Mead NJ, US
Arthur M. Doweyko - Long Valley NJ, US

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

A61K 31/5377
A61K 31/506
A61K 31/501
A61K 31/497
A61K 31/496
A61K 31/4439
A61K 31/427
A61K 31/426
A61K 31/4196
A61K 31/4168

US Classification:

5142355, 51425213, 51425205, 5142531, 51425402, 514256, 514274, 514340, 514342, 514371, 514383, 514398, 514392, 544111, 544238, 544298, 544359, 5462681, 5462684, 548190, 5483147, 5483325, 5482654, 548233, 5483044

Abstract:

The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associated diseases, and have the structure.