John R Hamman

US Patent:

20020193342, Dec 19, 2002

Filed:

May 9, 2001

Appl. No.:

09/852182

Inventors:

John Hamman - Baltimore MD, US
Gary Calton - Elkridge MD, US

International Classification:

A61K031/715
A61K038/00

US Classification:

514/053000, 424/439000, 514/400000, 514/419000, 514/002000

Abstract:

Masking compositions are provided comprising at least one unpleasant tasting amino acid other than arginine, protein hydrolysate and/or protein component wherein the taste of the unpleasant tasting component is masked with the addition of sucralose to provide organoleptically acceptable compositions. Masking compositions in accordance with the invention may then be incorporated in beverages, foods, bars, or candies to provide nutrient products.

US Patent:

20100119692, May 13, 2010

Filed:

Nov 12, 2009

Appl. No.:

12/590639

Inventors:

John P. Hamman - Baltimore MD, US
Gary Jim Calton - Elkridge MD, US

International Classification:

A23L 1/09

US Classification:

426658

Abstract:

Masking compositions are provided comprising at least one unpleasant tasting amino acid other than arginine, protein hydrolysate and/or protein component wherein the taste Of the unpleasant tasting component is masked with the addition of sucralose to provide organoleptically acceptable compositions. Masking compositions in accordance with the invention may then be incorporated in beverages, foods, bars, or candies to provide nutrient products.

US Patent:

51089165, Apr 28, 1992

Filed:

Jun 5, 1989

Appl. No.:

7/361049

Inventors:

Carrington S. Cobbs - Ellicott City MD
Michael J. Barton - Rockville MD
Lin Peng - Baltimore MD
Animesh Goswami - Columbia MD
Adrien P. Malick - Woodstock MD
John P. Hamman - Baltimore MD
Gary J. Calton - Elkridge MD

Assignee:

Rhone-Poulenc Rorer, S.A. - Antony

International Classification:

C12P 762
C12P 742
C12N 1100
C12N 920

US Classification:

435135

Abstract:

An immobilized isozyme of Lipase MY or AY from Candida rugosa is used for stereoselectively hydrolyzing racemic mixtures of esters of 2-substituted acids, other than 2-halo propionic acids, transesterifying esters or acids or esterify acids or alcohols, at high enantiomeric excess, in an organic solvent. Immobilization of the isozyme may be carried out in the presence of an organic acid such as stearic acid. The immobilized isozyme may be used with a fatty acid or fatty acid ester that increases stereoselectivity or rate of hydrolysis of a mixture of racemic esters.

US Patent:

56771622, Oct 14, 1997

Filed:

May 1, 1995

Appl. No.:

8/432955

Inventors:

Jinsheng Zou - Bronx NY
John Hamman - Baltimore MD
Gerard Marx - New York NY
Bernard Horowitz - New Rochelle NY

Assignee:

New York Blood Center, Inc. - New York NY

International Classification:

C12N 974
C12N 704
C12N 706
A61K 3848

US Classification:

435214

Abstract:

The present invention provides a method for activating prothrombin to thrombin in a prothrombin complex composition comprising at least prothrombin, Factors V, VII, IX, and X, and phospholipid, comprising the steps of: (a) cold-incubating the prothrombin complex composition with 2-15 mM of Ca. sup. 2+ ions at a pH of 6. 5-8. 0 and at a temperature of 2. degree. -8. degree. C. until Factor VII contained in the composition is activated; and (b) incubating the cold-incubated composition at a pH of 6. 5-8. 0 and at a temperature of 10. degree. -25. degree. C. for a period of time sufficient to activate prothrombin contained in the composition to thrombin.