John H Hess

US Patent:

20030036633, Feb 20, 2003

Filed:

Oct 22, 2001

Appl. No.:

10/007343

Inventors:

David Linemeyer - Westfield NJ, US
John Hess - Westfield NJ, US
Joseph Borkowski - Westfield NJ, US
Kathleen Bierilo - Matawan NJ, US
John Menke - Morganville NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07K014/705
C12P021/02
C12N005/06
C07H021/04

US Classification:

530/350000, 536/023500, 435/069100, 435/325000, 435/320100

Abstract:

DNAs encoding bradykinin Breceptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind des-Argkallidin and other B-specific ligands. The DNA has been expressed in recombinant host cells which produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

US Patent:

63070278, Oct 23, 2001

Filed:

May 10, 1999

Appl. No.:

9/307912

Inventors:

David L. Linemeyer - Westfield NJ
John W. Hess - Westfield NJ
Joseph A. Borkowski - Westfield NJ
Kathleen K. Bierilo - Matawan NJ
John G. Menke - Morganville NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07K 1628

US Classification:

53038822

Abstract:

DNAs encoding bradykinin B. sub. 1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind desArg. sup. 10 kallidin and other B. sub. 1 -specific ligands. The DNA has been expressed in recombinant host cells which produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

US Patent:

57508267, May 12, 1998

Filed:

Dec 2, 1996

Appl. No.:

8/759848

Inventors:

Joseph A. Borkowski - Westfield NJ
Howard Y. Chen - Westfield NJ
John W. Hess - Westfield NJ
Catherine D. Strader - Verona NJ
Myrna E. Trumbauer - Yardley PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 4900
C12N 1500
C12N 1509

US Classification:

800 2

Abstract:

A transgenic non-human animal with alterations in a bradykinin B2 receptor gene is prepared by introduction of a gene encoding an altered bradykinin B2 receptor into a host non-human animal.

US Patent:

59653671, Oct 12, 1999

Filed:

Sep 17, 1997

Appl. No.:

8/932761

Inventors:

David L. Linemeyer - Westfield NJ
John W. Hess - Westfield NJ
Joseph A. Borkowski - Westfield NJ
Kathleen K. Bierilo - Matawan NJ
John G. Menke - Morganville NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12Q 168
G01N 3353

US Classification:

435 6

Abstract:

DNAs encoding bradykinin B. sub. 1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind des-Arg. sup. 10 kallidin and other B. sub. 1 -specific ligands. The DNA has been expressed in recombinant host cells which produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

US Patent:

57121117, Jan 27, 1998

Filed:

Apr 15, 1994

Appl. No.:

8/229418

Inventors:

David L. Linemeyer - Westfield NJ
John W. Hess - Westfield NJ
Joseph A. Borkowski - Westfield NJ
Kathleen K. Bierilo - Matawan NJ
John G. Menke - Morganville NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12N 1512
C12N 510

US Classification:

435 691

Abstract:

DNAs encoding bradykinin B. sub. 1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind des-Arg. sup. 10 kallidin and other B. sub. 1 -specific ligands. The DNA has been expressed in recombinant host cells which produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

US Patent:

60079983, Dec 28, 1999

Filed:

Apr 21, 1997

Appl. No.:

8/837635

Inventors:

Charles I. Rosenblum - Kendall Park NJ
Leonardus H. T. Van Der Ploeg - Scotch Plains NJ
Sajjad A. Qureshi - Avenel NJ
Doris F. Cully - Scotch Plains NJ
John W. Hess - Lansdale PA
Michael R. Tota - Middletown NJ
Fang Chen - North Wales PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

G01N 3353
G01N 3350

US Classification:

435 71

Abstract:

A trans-activation assay for leptin is described. Leptin response elements are located proximal to a promoter, and the promoter region is operatively linked to a reporter gene. When leptin binds with the receptor, the reporter gene is transcribed.

US Patent:

20170057200, Mar 2, 2017

Filed:

Nov 15, 2016

Appl. No.:

15/352268

Inventors:

John VON HESS - Mays Landing NJ, US

Assignee:

ABsecon Mills Inc. - Cologne NJ

International Classification:

B32B 5/02
B32B 5/12
B32B 5/26
F41H 1/02

Abstract:

An antiballistic fabric comprises a first fabric ply made of two outer fabric layers separated by at least one inner fabric layer, each of the layers being constructed only from weft fibers laid at angles between about +30 and −30 degrees from the warp and the fibers of the outer layer form non-complementary angles with the fibers of the inner layers, the layers being knitted together in the z-direction. A second equivalent fabric ply is aligned and bound above the first fabric ply.

US Patent:

20150323288, Nov 12, 2015

Filed:

Jun 27, 2014

Appl. No.:

14/318407

Inventors:

- Cologne NJ, US
John VON HESS - Mays Landing NJ, US

Assignee:

ABSECON MILLS INC. - Cologne NJ

International Classification:

F41H 1/02
B32B 5/12
B32B 5/26
B32B 5/02

Abstract:

An antiballistic fabric comprises a first fabric ply made of two outer fabric layers separated by at least one inner fabric layer, each of the layers being constructed only from weft fibers laid at angles between about +30 and −30 degrees from the warp and the fibers of the outer layer form non-complementary angles with the fibers of the inner layers, the layers being knitted together in the z-direction. A second equivalent fabric ply is aligned and bound above the first fabric ply.