John C Jewett

US Patent:

8519122, Aug 27, 2013

Filed:

Feb 10, 2011

Appl. No.:

13/024908

Inventors:

John C. Jewett - Berkeley CA, US
Carolyn Ruth Bertozzi - Berkeley CA, US
Ellen May Sletten - Berkeley CA, US
Chelsea Gloria Gordon - Berkeley CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07D 225/04

US Classification:

540451, 540461

Abstract:

Provided are modified cycloalkyne compounds; and methods of use of such compounds in modifying biomolecules. Embodiments include a cycloaddition reaction that can be carried out under physiological conditions. The cycloaddition reaction involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo and in vitro.

US Patent:

20210116460, Apr 22, 2021

Filed:

Dec 22, 2020

Appl. No.:

17/131153

Inventors:

Jacob Schwartz - Tucson AZ, US
John C. Jewett - Tucson AZ, US
Mahta Moinpour - Tucson AZ, US

International Classification:

G01N 33/68

Abstract:

Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule. The present invention may be used for detecting or monitoring a disease or condition such as a protein misfolding disease (proteopathy), e.g., amyotrophic lateral sclerosis (ALS), etc.

US Patent:

20190041385, Feb 7, 2019

Filed:

Oct 11, 2018

Appl. No.:

16/158074

Inventors:

- Tucson AZ, US
John C. Jewett - Tucson AZ, US
Mahta Moinpour - Tucson AZ, US
Mehrdad Shadmehr - Tucson AZ, US

International Classification:

G01N 33/533
G01N 33/574
G01N 33/68
G01N 33/52

Abstract:

Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule. The present invention may be used for detecting or monitoring a disease or condition such as a protein misfolding disease (proteopathy), e.g., amyotrophic lateral sclerosis (ALS), etc.

US Patent:

20180000929, Jan 4, 2018

Filed:

Sep 14, 2017

Appl. No.:

15/704977

Inventors:

- Oakland CA, US
Mary Sloan Siegrist Palmore - Berkeley CA, US
John C. Jewett - Berkeley CA, US
Chelsea G. Gordon - Berkeley CA, US
Peyton Shieh - La Jolla CA, US

International Classification:

A61K 39/385
A61K 47/64
C12Q 1/18
C12N 1/20
C07K 14/47
C07K 9/00
C07K 14/195
C12Q 1/02
A61K 39/00

Abstract:

The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker.

US Patent:

20170021013, Jan 26, 2017

Filed:

Mar 31, 2016

Appl. No.:

15/087348

Inventors:

- Oakland CA, US
Mary Sloan Siegrist Palmore - Berkeley CA, US
John C. Jewett - Berkeley CA, US
Chelsea G. Gordon - Berkeley CA, US
Peyton Shieh - La Jolla CA, US

International Classification:

A61K 39/385
C12N 1/20
C12Q 1/02
C07K 14/195
A61K 47/48

Abstract:

The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker.

US Patent:

20140170183, Jun 19, 2014

Filed:

Nov 27, 2013

Appl. No.:

14/092262

Inventors:

- Oakland CA, US
Mary Sloan Siegrist Palmore - Berkeley CA, US
John C. Jewett - Berkeley CA, US
Chelsea G. Gordon - Berkeley CA, US
Peyton Shieh - Berkeley CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07K 9/00
C12Q 1/02
A61K 47/48

US Classification:

4241941, 530322, 4242791, 4352523, 435 29

Abstract:

The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker.