John R Jewett

US Patent:

8519122, Aug 27, 2013

Filed:

Feb 10, 2011

Appl. No.:

13/024908

Inventors:

John C. Jewett - Berkeley CA, US
Carolyn Ruth Bertozzi - Berkeley CA, US
Ellen May Sletten - Berkeley CA, US
Chelsea Gloria Gordon - Berkeley CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07D 225/04

US Classification:

540451, 540461

Abstract:

Provided are modified cycloalkyne compounds; and methods of use of such compounds in modifying biomolecules. Embodiments include a cycloaddition reaction that can be carried out under physiological conditions. The cycloaddition reaction involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo and in vitro.

US Patent:

20180000929, Jan 4, 2018

Filed:

Sep 14, 2017

Appl. No.:

15/704977

Inventors:

- Oakland CA, US
Mary Sloan Siegrist Palmore - Berkeley CA, US
John C. Jewett - Berkeley CA, US
Chelsea G. Gordon - Berkeley CA, US
Peyton Shieh - La Jolla CA, US

International Classification:

A61K 39/385
A61K 47/64
C12Q 1/18
C12N 1/20
C07K 14/47
C07K 9/00
C07K 14/195
C12Q 1/02
A61K 39/00

Abstract:

The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker.

US Patent:

20170021013, Jan 26, 2017

Filed:

Mar 31, 2016

Appl. No.:

15/087348

Inventors:

- Oakland CA, US
Mary Sloan Siegrist Palmore - Berkeley CA, US
John C. Jewett - Berkeley CA, US
Chelsea G. Gordon - Berkeley CA, US
Peyton Shieh - La Jolla CA, US

International Classification:

A61K 39/385
C12N 1/20
C12Q 1/02
C07K 14/195
A61K 47/48

Abstract:

The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker.

US Patent:

20140170183, Jun 19, 2014

Filed:

Nov 27, 2013

Appl. No.:

14/092262

Inventors:

- Oakland CA, US
Mary Sloan Siegrist Palmore - Berkeley CA, US
John C. Jewett - Berkeley CA, US
Chelsea G. Gordon - Berkeley CA, US
Peyton Shieh - Berkeley CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07K 9/00
C12Q 1/02
A61K 47/48

US Classification:

4241941, 530322, 4242791, 4352523, 435 29

Abstract:

The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker.