John F Jewett

US Patent:

20210116460, Apr 22, 2021

Filed:

Dec 22, 2020

Appl. No.:

17/131153

Inventors:

Jacob Schwartz - Tucson AZ, US
John C. Jewett - Tucson AZ, US
Mahta Moinpour - Tucson AZ, US

International Classification:

G01N 33/68

Abstract:

Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule. The present invention may be used for detecting or monitoring a disease or condition such as a protein misfolding disease (proteopathy), e.g., amyotrophic lateral sclerosis (ALS), etc.

US Patent:

20190041385, Feb 7, 2019

Filed:

Oct 11, 2018

Appl. No.:

16/158074

Inventors:

- Tucson AZ, US
John C. Jewett - Tucson AZ, US
Mahta Moinpour - Tucson AZ, US
Mehrdad Shadmehr - Tucson AZ, US

International Classification:

G01N 33/533
G01N 33/574
G01N 33/68
G01N 33/52

Abstract:

Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule. The present invention may be used for detecting or monitoring a disease or condition such as a protein misfolding disease (proteopathy), e.g., amyotrophic lateral sclerosis (ALS), etc.