John J Judge

US Patent:

7393534, Jul 1, 2008

Filed:

Jul 15, 2004

Appl. No.:

10/892659

Inventors:

Charles Aylsworth - Holt MI, US
Siu-Cheong Ho - East Lansing MI, US
David Juckett - East Lansing MI, US
John W. Judge - Holt MI, US
Igor V. Zlatkin - Lansing MI, US
Tatiana Zlatkin - Lansing MI, US

Assignee:

Barros Research Institute - Holt MI

International Classification:

A61K 38/00
A61K 39/00

US Classification:

4241851, 514 2

Abstract:

The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.