John R Keiser

US Patent:

40842665, Apr 18, 1978

Filed:

Nov 1, 1976

Appl. No.:

5/737271

Inventors:

Victor L. Poirier - Chelmsford MA
John T. Keiser - Acton MA

Assignee:

The United States of America as represented by the Secretary of Health,
Education and Welfare - Washington DC

International Classification:

A61F 100
A61F 124
A61M 103

US Classification:

3 1

Abstract:

Blood-contacting surfaces of artificial implant devices which have been flocked with fibers of a blood-compatible polymeric material to promote formation of a stable and viable biological lining when the device has been implanted in a living body, are treated to strengthen the bonds between the fibers and the substrate surface and to interlock the fibers with each other so as to substantially reduce the possibility of fiber separation and release from the substrate surface into the blood stream. The treatment is effected by applying to the flocked surface a dilute solution of an adhesive material in a solvent therefor, the content of the adhesive material in the treating solution being controlled so as to be sufficient to coat the fibers only at their points of contact with each other and with the substrate surface. When the solvent is thereafter evaporated from the substrate surface, secondary bonds of adhesive material are formed at such points of contact, leaving the fibers otherwise uncoated so as not to interfere with their biologicial lining formation-promoting properties.

US Patent:

40163032, Apr 5, 1977

Filed:

Aug 6, 1975

Appl. No.:

5/602385

Inventors:

Victor L. Poirier - Chelmsford MA
John T. Keiser - Acton MA

Assignee:

The United States of America - Washington DC

International Classification:

A61K 500
B05D 114
B05D 116
A61F 100

US Classification:

427 2

Abstract:

Blood-contacting surfaces of artificial implant devices which have been flocked with fibers of a blood-compatible polymeric material to promote formation of a stable and viable biological lining when the device has been implanted in a living body, are treated to strengthen the bonds between the fibers and the substrate surface and to interlock the fibers with each other so as to substantially reduce the possibility of fiber separation and release from the substrate surface into the blood stream. The treatment is effected by applying to the flocked surface a dilute solution of an adhesive material in a solvent therefor, the content of the adhesive material in the treating solution being controlled so as to be sufficient to coat the fibers only at their points of contact with each other and with the substrate surface. When the solvent is thereafter evaporated from the substrate surface, secondary bonds of adhesive material are formed at such points of contact, leaving the fibers otherwise uncoated so as not to interfere with their biological lining formation-promoting properties.