John Chaney Kirkwood

US Patent:

8227574, Jul 24, 2012

Filed:

Dec 5, 2007

Appl. No.:

11/951324

Inventors:

Mikhail Vitoldovich Paukshto - Foster City CA, US
David Harwood McMurtry - Felton CA, US
Gerald G. Fuller - Stanford CA, US
Yuri Alexandrovich Bobrov - Menlo Park CA, US
John E. Kirkwood - Santa Clara CA, US

Assignee:

Fibralign Corporation - Sunnyvale CA
The Board of Trustees of the Leland Stanford Junior University - Stanford CA

International Classification:

A61K 38/17

US Classification:

530356

Abstract:

In general, the present invention is related to collagen compositions and thin films, and to methods of making and using the same. In some embodiments, the present invention is directed to “woven pattern” or “basket pattern” collagen compositions and thin films, and methods of making.

US Patent:

8329246, Dec 11, 2012

Filed:

Mar 2, 2010

Appl. No.:

12/660702

Inventors:

Gerald G. Fuller - Stanford CA, US
John E. Kirkwood - Santa Clara CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61L 33/14

US Classification:

427 224, 623917, 435395, 514 172, 514 186

Abstract:

Techniques for the production of flow-oriented collagen gels using hydrodynamics to influence the assembly of collagen fibers. Highly concentrated monomeric solutions of collagen are subjected to shear and extensional flow as they are drawn onto a substrate to induce fibrillogenesis under a high Ph buffer. The produced gel captures the flow induced ordering of molecular collagen upon fibril formation. The depositing or the induction of fibrillogenosis occurs without the application of a magnetic field to the concentration of collagen. These highly oriented 3D scaffolds are capable inducing contact guidance and guiding mammalian cell growth. The collagen fibers mimic the construction of in vivo fibers with the characteristic D-periodicity and the integrin receptors on the fibroblasts respond to this organization. The industrial applications of three-dimensional collagen gels as a biomaterial are widespread from drug delivery to burn repair or tissue engineering system.

US Patent:

8597717, Dec 3, 2013

Filed:

Nov 8, 2012

Appl. No.:

13/671671

Inventors:

John E. Kirkwood - Los Gatos CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61L 27/24
A61L 27/50
A61L 33/14
B05D 5/00
C08J 5/00
C08L 89/06

US Classification:

427 224, 623917, 435395, 514 172, 514 186

Abstract:

Techniques for the production of flow-oriented collagen gels using hydrodynamics to influence the assembly of collagen fibers. Highly concentrated monomeric solutions of collagen are subjected to shear and extensional flow as they are drawn onto a substrate to induce fibrillogenesis under a high Ph buffer. The produced gel captures the flow induced ordering of molecular collagen upon fibril formation. The depositing or the induction of fibrillogenosis occurs without the application of a magnetic field to the concentration of collagen. These highly oriented 3D scaffolds are capable inducing contact guidance and guiding mammalian cell growth. The collagen fibers mimic the construction of in vivo fibers with the characteristic D-periodicity and the integrin receptors on the fibroblasts respond to this organization. The industrial applications of three-dimensional collagen gels as a biomaterial are widespread from drug delivery to burn repair or tissue engineering system.

US Patent:

20060234572, Oct 19, 2006

Filed:

Oct 27, 2005

Appl. No.:

11/260742

Inventors:

Norman Wagner - Newark DE, US
John Kirkwood - Stanford CA, US
Ronald Egres - Newark DE, US

Assignee:

UD Technology Corporation - Newark DE

International Classification:

B32B 5/02

US Classification:

442059000

Abstract:

The rheology of a colloidal PEG-based shear thickening fluid emulsified with silicone oil is studied in detail. A shear thickening response is observed in the viscosity-shear rate curves for volume fractions as low as 10% of STF in the silicone emulsion. From the log additivity rule, we prove the system to be classified as both a positive and negative deviating blend at zero shear. This interesting behavior is due to phase inversion. The rubbers are formed by emulsifying the shear thickening fluid within the rubber precursors and then adding the catalyzing agent. It was possible to contain STF in each of the silicones tested and the rubbers exhibited different behavior with incased STF. Shear thickening fluid was added to open cell polyurethane to create a Foam-STF composite which was found to exhibit an obvious shear thickening response. The foam composite became solid like and absorbed energy at high strains while still maintaining its fluid-like response at low strain rates.

US Patent:

20100221521, Sep 2, 2010

Filed:

Sep 7, 2006

Appl. No.:

11/516956

Inventors:

Norman Wagner - Newark DE, US
John E. Kirkwood - Stanford CA, US

Assignee:

UNIVERSITY OF DELAWARE OFFICE OF THE VICE PROVOST FOR RESEARCH - Newark DE

International Classification:

B32B 3/26
B32B 5/16
C08L 75/04
C08L 63/00
C08L 23/00
C08L 23/06
C08L 23/12
C08L 33/12
C08L 27/06
C08L 31/00
C08L 77/00
C08J 9/00

US Classification:

4283155, 428323, 4283044, 524589, 524612, 524570, 524585, 524582, 524560, 524567, 524556, 524606, 521 50

Abstract:

Shear thickening fluid suspoemulsions are shown to exhibit unique material properties that have potential application in a broad range of fields of use. Suspoemulsions containing shear thickening fluids as immiscible blends exhibit a nontrivial shear thickening response for volume fractions as low as 10% of STF in the silicone emulsion. Measurements indicate that the system shows phase inversion and it is even possible to form materials with a cocontinuous microstructure with interesting, hysteretic, shear sensitive behavior. Novel STF containing composites with rubbers are formed by blending the shear thickening fluid within the rubber precursors and then adding the catalyzing agent. It was possible to contain STF in each of the silicones tested and the rubbers exhibited different behavior with incased STF. Shear thickening fluid was added to open cell polyurethane to create a Foam-STF composite which was found to exhibit an significant shear thickening response. Finally, STF composites were also formed by polymer blending, leading to materials with unique and superior performance as a consequence of the STF content and multiphase microstructure.