John B Kisiel

US Patent:

20130244235, Sep 19, 2013

Filed:

Feb 22, 2013

Appl. No.:

13/773791

Inventors:

William R. Taylor - Lake City MN, US
Tracy C. Yab - Rochester MN, US
John B. Kisiel - Rochester MN, US

Assignee:

Mayo Foundation for Medical Education and Research - Rochester MN

International Classification:

C12Q 1/68

US Classification:

435 611

Abstract:

The present invention provides methods and materials related to the detection of colorectal neoplasia (CRN) associated with inflammatory bowel disease (IBD). The present invention provides markers specific for colorectal neoplasia associated with inflammatory bowel disease in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals (e.g., humans) having colorectal neoplasia associated with inflammatory bowel disease by detecting the presence and level of indicators of colorectal neoplasia such as, for example, epigenetic alterations (e.g., DNA methylation) (e.g., CpG methylation) (e.g., CpG methylation in coding or regulatory regions of BMP3, NDRG4, vimentin, EYA4) in DNA from a stool sample obtained from the mammal.

US Patent:

20220349009, Nov 3, 2022

Filed:

Apr 22, 2022

Appl. No.:

17/727128

Inventors:

- Rochester MN, US
- Madison WI, US
Douglas W. Mahoney - Elgin MN, US
John B. Kisiel - Rochester MN, US
David A. Ahlquist - Rochester MN, US
Hatim T. Allawi - Middleton WI, US
Graham P. Lidgard - Madison WI, US

International Classification:

C12Q 1/6883
C12Q 1/6806

Abstract:

Provided herein is technology for screening for esophageal disorders, including but not limited to, Barrett's esophagus (BE). In particular, provided herein are methods, compositions, and related uses for detecting the presence or absence of esophageal disorders from a biological sample.

US Patent:

20220243278, Aug 4, 2022

Filed:

Jan 28, 2022

Appl. No.:

17/587963

Inventors:

- Rochester MN, US
- Madison WI, US
Viatcheslav E. Katerov - Madison WI, US
John B. Kisiel - Rochester MN, US
Douglas W. Mahoney - Rochester MN, US
David A. Ahlquist - Rochester MN, US

International Classification:

C12Q 1/6886
C12Q 1/6806
G01N 33/574

Abstract:

Provided herein is technology for screening multiple types of cancer from a biological sample, and particularly, but not exclusively, to methods, compositions, and related uses for simultaneously detecting the presence of multiple types of cancer (e.g., liver cancer, esophageal cancer, lung cancer, ovarian cancer, pancreatic cancer, gastric cancer, bladder cancer, breast cancer, cervical cancer, colorectal cancer, prostate cancer, renal cancer, and uterine cancer) from a biological sample (e.g., stool sample, tissue sample, organ secretion sample, CSF sample, saliva sample, blood sample, plasma sample or urine sample).

US Patent:

20230028856, Jan 26, 2023

Filed:

Jul 11, 2022

Appl. No.:

17/811677

Inventors:

- Rochester MN, US
William R. Taylor - Lake City MN, US
John B. Kisiel - Rochester MN, US
Douglas W. Mahoney - Elgin MN, US
Tracy C. Yab - Rochester MN, US

International Classification:

C12Q 1/6886

Abstract:

Provided herein is technology for gastrointestinal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of gastrointestinal neoplasm, and classifying the site location of such a gastrointestinal neoplasm (e.g., a colorectal region, a pancreaticobiliary region, a gastroesophageal region).

US Patent:

20210381066, Dec 9, 2021

Filed:

Aug 24, 2021

Appl. No.:

17/410383

Inventors:

- Madison WI, US
- Rochester MN, US
John B. Kisiel - Rochester MN, US
Douglas W. Mahoney - Elgin MN, US
Tracy C. Yab - Rochester MN, US
Graham P. Lidgard - Middleton WI, US
Hatim T. Allawi - Middleton WI, US

International Classification:

C12Q 1/6886
C12Q 1/6883
G01N 33/574

Abstract:

Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).

US Patent:

20210317538, Oct 14, 2021

Filed:

Jun 14, 2021

Appl. No.:

17/347027

Inventors:

- Rochester MN, US
William R. Taylor - Lake City MN, US
John B. Kisiel - Rochester MN, US
Tracy C. Yab - Rochester MN, US
Douglas W. Mahoney - Rochester MN, US

International Classification:

C12Q 1/6886

Abstract:

Provided herein is technology for pancreatic high-grade dysplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of pancreatic high-grade dysplasia (IPMN-HGD, PanIN-3, or PDAC).

US Patent:

20210207224, Jul 8, 2021

Filed:

Mar 18, 2021

Appl. No.:

17/205796

Inventors:

- Rochester MN, US
- Madison WI, US
Douglas W. Mahoney - Elgin MN, US
Tracy C. Yab - Rochester MN, US
John B. Kisiel - Rochester MN, US
Hatim T. Allawi - Middleton WI, US
Graham P. Lidgard - Middleton WI, US
Michael W. Kaiser - Stoughton WI, US

International Classification:

C12Q 1/6886
C12Q 1/6853
G16H 50/30
C12Q 1/6806
C12Q 1/6809
C12Q 1/6811
C12Q 1/6837
C12Q 1/6827
C12Q 1/682

Abstract:

Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.

US Patent:

20210130911, May 6, 2021

Filed:

Jan 8, 2021

Appl. No.:

17/144806

Inventors:

- Rochester MN, US
- Madison WI, US
John B. Kisiel - Rochester MN, US
Tracy C. Yab - Rochester MN, US
Douglas W. Mahoney - Elgin MN, US
Brian A. Dukek - Rochester MN, US
Matthew T. Gettman - Rochester MN, US
Hatim T. Allawi - Middleton WI, US

International Classification:

C12Q 1/6886

Abstract:

Provided herein is technology for prostate cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of prostate cancer.