John A Kyncl

US Patent:

42698588, May 26, 1981

Filed:

Apr 28, 1980

Appl. No.:

6/144742

Inventors:

John F. DeBernardis - Lake Villa IL
John J. Kyncl - Lake Forest IL

Assignee:

Abbott Laboratories - North Chicago IL

International Classification:

A61K 31135

US Classification:

424330

Abstract:

2-Fluoronorepinephrine has been found to have antihypertensive activity when orally administered to warm-blooded animals.

US Patent:

52121763, May 18, 1993

Filed:

Jun 29, 1990

Appl. No.:

7/546349

Inventors:

John J. Kyncl - Lake Forest IL
Bruce W. Horrom - Waukegan IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31505
C07D23984

US Classification:

514254

Abstract:

R(+)-2-[4-[(tetrahydro-2-furanyl)carbonyl]-1-piperazinyl]-6,7-dimethoxy-4-q uinazolinamine hydrochloride or a pharmaceutically acceptable salt or hydratet hereof (terazosin), substantially free of the S(-)-enantiomer.

US Patent:

41761910, Nov 27, 1979

Filed:

Nov 6, 1978

Appl. No.:

5/958272

Inventors:

Martin Winn - Deerfield IL
John J. Kyncl - Lake Forest IL

Assignee:

Abbott Laboratories - North Chicago IL

International Classification:

A61K 3140
C07D20934

US Classification:

424274

Abstract:

This invention provides aminomethylene oxindole compounds represented by the formula ##STR1## wherein R is H or loweralkyl; R' is loweralkyl, aralkyl, or R and R' taken together form a chain of the formula --CH. sub. 2 CH. sub. 2 X CH. sub. 2 CH. sub. 2 -- wherein X is CH. sub. 2 or NR" where R" is loweralkyl, loweralkanoyl, aroyl, alkoxycarbonyl or aryl; and the pharmaceutically acceptable acid addition salts thereof. The compounds of this invention are useful as antihypertensive agents.

US Patent:

42267730, Oct 7, 1980

Filed:

May 7, 1979

Appl. No.:

6/036883

Inventors:

John J. Kyncl - Lake Forest IL

Assignee:

Abbott Laboratories - North Chicago IL

International Classification:

A61K 3140
A61K 3147
A61K 31415
A61K 31435

US Classification:

424273P

Abstract:

Described is a method of increasing urinary excretion by administering effective amounts to a subject in need thereof of compounds of the formula ##STR1## wherein R. sub. 1 and R. sub. 2 are hydrogen, loweralkyl, lowercycloalkyl, aralkyl, aryl, pyridyl, isoquinolyl or phthalazinyl, or aryl substituted by one or more hydrogen, halo, loweralkyl, lowercycloalkyl, haloloweralkyl, aminosulfonyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, cycloalkoxy carbonyl, aminocarbonyl, diloweralkylaminocarbonyl or ##STR2## wherein n is 4 or 5. R. sub. 3 is hydrogen, halogen, loweralkyl or aryl, and R. sub. 4 is hydrogen, acyl, amino or loweralkyl, and the pharmaceutically acceptable acid addition salts thereof.

US Patent:

41454227, Mar 20, 1979

Filed:

Sep 6, 1977

Appl. No.:

5/830722

Inventors:

Martin Winn - Deerfield IL
John J. Kyncl - Lake Forest IL

Assignee:

Abbott Laboratories - North Chicago IL

International Classification:

A61K 31495
C07D40100
C07D40300

US Classification:

424250

Abstract:

This invention provides aminomethylene oxindole compounds represented by the formula ##STR1## wherein R is H or loweralkyl; R' is loweralkyl, aralkyl, or R and R' taken together form a chain of the formula --CH. sub. 2 CH. sub. 2 XCH. sub. 2 CH. sub. 2 -- wherein X is CH. sub. 2 or NR" where R" is loweralkyl, loweralkanoyl, aroyl, alkoxycarbonyl or aryl; and the pharmaceutically acceptable acid addition salts thereof. The compounds of this invention are useful as antihypertensive agents.