John J Lis

Address:

165 Normanskill Rd, Slingerlands, NY 12159

Phone:

(518)7652670

VIN:

4JGBB86E77A287227

Make:

MERCEDES-BENZ

Model:

M-CLASS

Year:

2007

US Patent:

7601823, Oct 13, 2009

Filed:

Oct 24, 2005

Appl. No.:

11/256726

Inventors:

Li Niu - Loundonville NY, US
Zhen Huang - Albany NY, US
Hua Shi - Ithaca NY, US
John T. Lis - Ithaca NY, US

Assignee:

Cornell University - Ithaca NY
The Research Foundation of State University of New York - Albany NY

International Classification:

C07H 21/02

US Classification:

536 231, 506 16, 506 13, 506 23, 506 7

Abstract:

The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i. e. , SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.

US Patent:

8076467, Dec 13, 2011

Filed:

Oct 13, 2009

Appl. No.:

12/578231

Inventors:

Li Niu - Loudonville NY, US
Zhen Huang - Albany NY, US
Hua Shi - Ithaca NY, US
John T. Lis - Ithaca NY, US

Assignee:

The Research Foundation of State University of New York - Albany NY
Cornell University - Ithaca NY

International Classification:

C07H 21/02
C07H 21/04
C40B 40/06
C40B 40/00
C40B 50/00
C40B 30/00
A61K 48/00

US Classification:

536 231, 506 16, 506 13, 506 23, 506 7, 514 44 R

Abstract:

The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i. e. , SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.

US Patent:

8450468, May 28, 2013

Filed:

Dec 12, 2011

Appl. No.:

13/323161

Inventors:

Li Niu - Loudonville NY, US
Zhen Huang - Albany NY, US
Hua Shi - Ithaca NY, US
John T. Lis - Ithaca NY, US

Assignee:

The Research Foundation for the State University of New York - Albany NY
Cornell University - Ithaca NY

International Classification:

A61K 48/00
C07H 19/00
C07H 21/00
C07H 21/02

US Classification:

536 221, 536 231, 514 44 R

Abstract:

The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i. e. , SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.